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02850nam a2200241Ia 4500 |
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10.1016-j.alcohol.2022.03.004 |
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220706s2022 CNT 000 0 und d |
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|a 07418329 (ISSN)
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|a Effects of chronic alcohol exposure on motivation-based value updating
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|b Elsevier Inc.
|c 2022
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|z View Fulltext in Publisher
|u https://doi.org/10.1016/j.alcohol.2022.03.004
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|a Dysfunctional decision-making has been observed in alcohol dependence. However, the specific underlying processes disrupted have yet to be identified. Important to goal-directed decision-making is one's motivational state, which is used to update the value of actions. As ethanol dependence disrupts decision-making processes, we hypothesized that ethanol dependence could alter sensitivity to motivational state and/or value updating, thereby reducing the capability for adaptive behavior. Here we employed a sequential instrumental learning task to examine this hypothesis. In two experiments, mice underwent chronic intermittent ethanol (CIE) or air (Air) vapor exposure and repeated withdrawal procedures to induce ethanol dependence. Mice were then trained on a sequence of distal and proximal lever pressing for sucrose under either mild or more severe food restriction. Half of all Air and CIE mice then underwent a motivational shift to a less hungry state and effects of this motivational shift were evaluated across three days. First, mice were re-exposed to sucrose, and effects of food restriction state and CIE exposure on lick and consummatory behavior were examined in the absence of lever pressing. Over the next two days, mice underwent a brief non-rewarded test and then a rewarded test where the ability to retrieve and infer sucrose value to guide lever pressing was measured. In the sucrose re-exposure session, prior CIE exposure altered sucrose-seeking in mice with a history of mild but not more severe food restriction, suggesting altered motivational sensitivity. During lever press testing, CIE mice were insensitive to decreases in motivational state and did not reduce proximal lever pressing regardless of food restriction state. Mildly restricted CIE mice, but not severely restricted CIE mice, also did not reduce distal pressing to the same degree as Air mice following a downshift in motivational state. Our findings suggest that ethanol dependence may disrupt motivational processes supporting value updating that are important for decision-making. © 2022 The Authors
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|a alcohol use disorder
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|a decision-making
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|a goal-directed
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|a incentive learning
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|a mice
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|a motivational state
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|a Baltz, E.T.
|e author
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|a Gremel, C.M.
|e author
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|a Shields, C.N.
|e author
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|a Valencia, M.L.
|e author
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|t Alcohol
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