Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish
Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), increases the serotonin levels in the brain to treat depression. Antidepressants have been demonstrated to modulate circadian rhythm, but the underlying mechanisms by which antidepressants regulate circadian rhythm require more resea...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Masson s.r.l.
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |
| LEADER | 02010nam a2200325Ia 4500 | ||
|---|---|---|---|
| 001 | 10.1016-j.biopha.2022.113268 | ||
| 008 | 220718s2022 CNT 000 0 und d | ||
| 020 | |a 07533322 (ISSN) | ||
| 245 | 1 | 0 | |a Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish |
| 260 | 0 | |b Elsevier Masson s.r.l. |c 2022 | |
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.1016/j.biopha.2022.113268 | ||
| 520 | 3 | |a Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), increases the serotonin levels in the brain to treat depression. Antidepressants have been demonstrated to modulate circadian rhythm, but the underlying mechanisms by which antidepressants regulate circadian rhythm require more research. This study aimed to investigate the role of FLX on circadian rhythm by analyzing the movement behavior and internal circadian oscillations in zebrafish. The results showed that the expression of clock genes clock1a and bmal1b was significantly down-regulated, and the amplitude reduction and phase shift were observed after FLX treatment. Furthermore, FLX exposure inhibited the expression of aanat2, which led to a decrease in nocturnal melatonin secretion. aanat2-/- larvae showed disrupted circadian rhythm. These findings may help reveal the effect of FLX exposure on the circadian rhythm and locomotor activity. It may provide theoretical data for the clinical application of FLX. © 2022 The Authors | |
| 650 | 0 | 4 | |a Behavior |
| 650 | 0 | 4 | |a Circadian rhythms |
| 650 | 0 | 4 | |a Fluoxetine |
| 650 | 0 | 4 | |a Melatonin |
| 650 | 0 | 4 | |a Zebrafish |
| 700 | 1 | |a Chen, A.-Q. |e author | |
| 700 | 1 | |a Fan, Z.-X. |e author | |
| 700 | 1 | |a Hao, M.-X. |e author | |
| 700 | 1 | |a He, S.-M. |e author | |
| 700 | 1 | |a Liu, H.-R. |e author | |
| 700 | 1 | |a Liu, W. |e author | |
| 700 | 1 | |a Lv, S.-J. |e author | |
| 700 | 1 | |a Qiu, C.-Z. |e author | |
| 700 | 1 | |a Ren, D.-L. |e author | |
| 700 | 1 | |a Wei, M.-L. |e author | |
| 700 | 1 | |a Yin, Z.-J. |e author | |
| 700 | 1 | |a Zhang, L. |e author | |
| 773 | |t Biomedicine and Pharmacotherapy | ||