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01500nam a2200205Ia 4500 |
| 001 |
10.1016-j.ejcb.2022.151229 |
| 008 |
220706s2022 CNT 000 0 und d |
| 020 |
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|a 01719335 (ISSN)
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| 245 |
1 |
0 |
|a Tetraspanins interweave EV secretion, endosomal network dynamics and cellular metabolism
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| 260 |
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|b Elsevier GmbH
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1016/j.ejcb.2022.151229
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| 520 |
3 |
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|a Tetraspanin proteins organize membrane nanodomains related to cell adhesion and migration. An essential feature conserved along the superfamily is their cone-shaped tertiary structure, which allows tetraspanins to be enriched in highly curved membrane structures. Their conical shape, together with their ability to associate to transmembrane receptors and to bind to cystoskeletal and signaling scaffolds, are key in their ability to regulate endosomal network dynamics and Extracellular Vesicle biogenesis and cargo selection. Recent evidence suggests that tetraspanins have a relevant impact in mitochondria turnover and regulation of cellular metabolism. In this review we highlight those reports that point to tetraspanins as key regulators in the communication between the endosomal network, EVs and the cellular metabolism. © 2022 The Authors
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|a Autophagy
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| 650 |
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|a Endosomes
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| 650 |
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|a EVs
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| 650 |
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|a Metabolism
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| 650 |
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|a Tetraspanin
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| 700 |
1 |
0 |
|a Toribio, V.
|e author
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1 |
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|a Yáñez-Mó, M.
|e author
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| 773 |
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|t European Journal of Cell Biology
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