SARS-Cov-2 ORF3a: Mutability and function

SARS-Cov-2 ORF3a: Mutability and function

In this study, analysis of changes of SARS-CoV-2 ORF3a protein during pandemic is reported. ORF3a, a conserved coronavirus protein, is involved in virus replication and release. A set of 70,752 high-quality SARS-CoV-2 genomes available in GISAID databank at the end of August 2020 have been scanned....

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Bibliographic Details
Main Authors:	Bianchi, M. (Author), Borsetti, A. (Author), Ciccozzi, M. (Author), Pascarella, S. (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Subjects:	amino acid sequence Amino Acid Sequence Article chemistry conserved sequence Conserved Sequence Conserved sites controlled study COVID-19 Databases, Genetic dimer epidemiology Evolution, Molecular genetic database genetics Genome, Viral GISAID databank human Humans Models, Molecular molecular evolution molecular model monomer Mutated sites mutation Mutation nonhuman ORF3a ORF3a protein ORF3a protein, SARS-CoV-2 pandemic Pandemics physiology Pore protein domain protein function protein interaction protein quaternary structure protein stability protein structure Protein Structure, Quaternary proteome Proteome Q57H SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 tetramer tetramerization time factor Time Factors unclassified drug viral protein virology Viroporin Proteins virus genome virus mutation
Online Access:	View Fulltext in Publisher

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