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03307nam a2200481Ia 4500 |
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10.1016-j.jdent.2018.05.021 |
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220706s2018 CNT 000 0 und d |
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|a 03005712 (ISSN)
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|a In situ effect of Tooth Mousse containing CPP-ACP on human enamel subjected to in vivo acid attacks
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|b Elsevier Ltd
|c 2018
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|z View Fulltext in Publisher
|u https://doi.org/10.1016/j.jdent.2018.05.021
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|a Objective: This in situ study aimed to evaluate the protective effect of Tooth Mousse (GC) containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on human enamel erosion and to compare the difference in erosion between the anteriorly and posteriorly positioned human enamel. Methods: This study used a 2-treatment (7 days each) crossover design with 12 healthy volunteers wearing intraoral appliances. Each appliance contained 4 human enamel specimens positioned on the buccal surfaces of the volunteers’ maxillary central incisors and first molars. The specimens were intraorally treated withTooth Mousse (CPP-ACP group) or deionized water (control group) for 3 min and then exposed to in vivo acid attacks by rinsing with 150 ml of a cola drink (4 × 5 min/day). The surface microhardness (SMH) of the specimens was measured and used to calculate the percentage of SMH loss (%SMHl). Erosion effect on enamel was also investigated by scanning electron microscopy (n = 4) at the end of study. The data were statistically analysed using two-way analysis of variance (ANOVA) and Tukey's test at a level of P < 0.05. Results: A significant decrease in %SMHl was observed for the specimens of CPP-ACP group compared to that for the controls (P = 0.007). The specimens positioned posteriorly exhibited a significantly lower %SMHl than those positioned anteriorly (P = 0.033). Samples of CPP-ACP group showed fewer etching patterns than those of the control group. Conclusions: In this in situ model, application of Tooth Mousse containing CPP-ACP before erosion reduced the %SMHl of human enamel. Enamel located in different positions showed different patterns of erosion. Clinical significance: Application of Tooth Mousse containing CPP-ACP could be considered as a suitable preventive strategy against enamel erosion. ClinicalTrials.gov Identifier: NCT03426150. © 2018 Elsevier Ltd
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|a acid
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|a Acids
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|a carbonated beverage
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|a Carbonated Beverages
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|a casein
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|a casein phosphopeptide-amorphous calcium phosphate nanocomplex
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|a Caseins
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|a controlled study
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|a crossover procedure
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|a Cross-Over Studies
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|a Demineralization
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|a Dental Enamel
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|a dental procedure
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|a drug effect
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|a enamel
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|a Enamel
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|a Hardness
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|a human
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|a Humans
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|a randomized controlled trial
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|a tooth disease
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|a Tooth erosion
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|a Tooth Erosion
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|a Tooth Remineralization
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|a Attin, T.
|e author
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|a Cheng, H.
|e author
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|a Jiang, N.-W.
|e author
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|a Ye, X.-Y.
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|a Yu, H.
|e author
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|a Zheng, H.-Y.
|e author
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|t Journal of Dentistry
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