| Summary: | One of the greatest public health crises in recent times, the COVID-19 pandemic, has come with a myriad of challenges in terms of health communication and public cooperation to prevent the spread of the disease. Understanding which are the key determinants that make certain individuals more cooperative is key in effectively tackling pandemics and similar future challenges. In the present study (N = 800), we investigated whether gender differences in compliance with preventive health behaviors (PHB) at the onset of the COVID-19 pandemic could be established, and, if so, whether the personality traits of agreeableness and conscientiousness can help explain this presumed relationship. Consistent with our theorizing, we found women to score higher than men on agreeableness and conscientiousness, and to be more willing to comply with a set of PHB. Importantly, both personality traits were found to mediate the gender-compliance link. This means that women's greater compliance levels with PHB could, at least in part, be attributed to their higher agreeableness and conscientiousness scores. A greater understanding of the determinants of PHB in terms of gender and associated personality traits may help identify options for developing more effective communication campaigns, both in terms of communication channel selection and message content. © 2021
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