Artemisia absinthium improves spatial performance and neuronal injury induced by amyloid- beta in the CA1 hippocampal area of male Wistar rats

Alzheimer's disease is a neurodegenerative disorder. It is characterized by the presence of two aberrant structures in the brain, those are, amyloid plaques and neurofibrillary tangles, along with neuronal death. Amyloid-beta further exacerbates the metabolic decline and results in cognitive im...

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Bibliographic Details
Main Authors: Eslimi Esfahani, D. (Author), Kouchesfahani, H.M (Author), Oryan, S.H (Author), Salari, A. (Author), Taheri, M. (Author)
Format: Article
Language:English
Published: Academic Press Inc. 2021
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Online Access:View Fulltext in Publisher
LEADER 02391nam a2200241Ia 4500
001 10.1016-j.nlm.2021.107506
008 220427s2021 CNT 000 0 und d
020 |a 10747427 (ISSN) 
245 1 0 |a Artemisia absinthium improves spatial performance and neuronal injury induced by amyloid- beta in the CA1 hippocampal area of male Wistar rats 
260 0 |b Academic Press Inc.  |c 2021 
856 |z View Fulltext in Publisher  |u https://doi.org/10.1016/j.nlm.2021.107506 
520 3 |a Alzheimer's disease is a neurodegenerative disorder. It is characterized by the presence of two aberrant structures in the brain, those are, amyloid plaques and neurofibrillary tangles, along with neuronal death. Amyloid-beta further exacerbates the metabolic decline and results in cognitive impairments. Because of the favorable antioxidant and anti-inflammatory activities of Artemisia absinthium (wormwood), this study aimed to evaluate the effects of hydroalcoholic extract of this plant on spatial memory performance, neuronal injury, and apoptosis induced by amyloid-beta. Forty-eight male Wistar rats (220–250 g) were divided into the following groups: 1) control; 2) sham (solvent; ICV); 3) amyloid-beta 1–40 (ICV); and 4) amyloid-beta plus A. absinthium (10, 50, and 100 mg/kg/day; gavage). Congo red and TUNEL staining were performed to investigate the neuronal injury. Also, the Morris water maze (MWM) test was used to evaluate the spatial memory of the experimental groups. The results showed that spatial memory for finding the hidden platform in the MWM task decreased significantly in the amyloid-beta group, compared to the control and sham groups. In contrast, treatment with A. absinthium improved spatial memory dose-dependently and reduced tissue degeneration, amyloid plaques, and apoptosis. It seems that the hydroalcoholic extract of A. absinthium, due to its antioxidant and anti-inflammatory activities, can effectively reverse spatial memory deficits and reduce amyloid-beta plaques. © 2021 Elsevier Inc. 
650 0 4 |a Alzheimer 
650 0 4 |a Amyloid plaques 
650 0 4 |a Apoptosis 
650 0 4 |a Artemisia absinthium 
650 0 4 |a Morris water maze 
700 1 |a Eslimi Esfahani, D.  |e author 
700 1 |a Kouchesfahani, H.M.  |e author 
700 1 |a Oryan, S.H.  |e author 
700 1 |a Salari, A.  |e author 
700 1 |a Taheri, M.  |e author 
773 |t Neurobiology of Learning and Memory