Tongue schwannomas associated with neurofibromatosis type 2

• Main Authors: Kanazawa, H. (Author), Kasamatsu, A. (Author), Kita, A. (Author), Koide, N. (Author), Sawai, H. (Author), Uzawa, K. (Author), Yamatoji, M. (Author)
• Format: Article
• Language: English
• Published: Elsevier Inc 2018
• Subjects: acoustic neuroma; adult; Article; cancer diagnosis; case report; clinical article; clinical examination; dysphagia; enucleation; family history; female; follow up; hearing impairment; human; immunohistochemistry; medical history; meningioma; neurilemoma; neurofibromatosis type 2; Neurofibromatosis type 2 (NF2); nuclear magnetic resonance imaging; Oral manifestation; pons angle; priority journal; Schwannoma; spinal cord lesion; spindle cell; subcutaneous nodule; Tongue; tongue schwannoma
• Online Access: View Fulltext in Publisher

 Schwannomas are typically solitary benign neural tumors; however, multiple lesions associated with the rare genetic disorder neurofibromatosis type 2 (NF2) have been reported in some cases. We present the case of a tongue schwannomas in a 36-year-old woman previously diagnosed with NF2 with bilateral vestibular schwannomas. To alleviate difficulties with swallowing, tongue nodular masses were surgically removed, and schwannoma was histologically diagnosed. Our patient represents the first case of histologically confirmed tongue schwannoma associated with NF2. This indicates that in patient with NF2, schwannoma may be detected in the oral cavity as well as in other parts of the body. Thus, careful clinical and histological examinations are warranted to identify schwannomas associated with NF2 even in the oral cavity. © 2018 The Authors