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01815nam a2200265Ia 4500 |
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10.1016-j.phro.2022.03.005 |
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220425s2022 CNT 000 0 und d |
| 020 |
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|a 24056316 (ISSN)
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| 245 |
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|a Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients
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| 260 |
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|b Elsevier Ireland Ltd
|c 2022
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| 300 |
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|a 5
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1016/j.phro.2022.03.005
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|a Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 (68Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (DLCO). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26–0.88). 68Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with DLCO (≤0.59). Our findings suggested that 68Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients. © 2022 The Authors
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|a Lung cancer
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|a Lung function
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|a Positron emission tomography/computed tomography (PET/CT)
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|a Ventilation/perfusion
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| 700 |
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|a Callahan, J.
|e author
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|a Hardcastle, N.
|e author
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|a Hofman, M.S.
|e author
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|a Le Roux, P.-Y.
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|a Li, Z.
|e author
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|a Siva, S.
|e author
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|a Yamamoto, T.
|e author
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| 773 |
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|t Physics and Imaging in Radiation Oncology
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