Prior exposure to Hedione, a model of pheromone, does not affect female ratings of male facial attractiveness or likeability

• Main Authors: Croy, I. (Author), Haehner, A. (Author), Oleszkiewicz, A. (Author), Suhle, P. (Author)
• Format: Article
• Language: English
• Published: Elsevier Inc. 2021
• Subjects: adult; air; Article; association; Attractiveness; controlled study; cyclopentane derivative; Cyclopentanes; face; Face; facial recognition; female; Female; hedione; Hedione; heterosexual female; human; human experiment; Human pheromones; Humans; informed consent; male; Male; methyldihydrojasmonate; normal human; odor; Olfaction; Olfactory communication; ovulation; perception; phenethyl alcohol; pheromone; Pheromones; physical attractiveness; receptor; Smell; smelling; unclassified drug; velocity; vomeronasal organ; vomeronasal type 1 receptor
• Online Access: View Fulltext in Publisher

 The existence of pheromones in humans is controversial, partly because of definitional difficulties and partly because of the question of possible chemical substances. The synthetic compound Methyl dihydrojasmonate (Hedione) is potent to bind to vomeronasal-type 1 receptors (VN1R1s) and activate limbic areas of the brain in a sex-specific manner. However, one of the most important definitional points for a human pheromone effect has not yet been investigated, i.e., whether smelling Hedione, a model of pheromone, has a behavioral effect. We tested in females whether Hedione leads to altered perception of male social stimuli. Each of the included women were sensitive to Hedione and were tested around the time of ovulation in three consecutive sessions, during each they were exposed to either Hedione or Phenylethyl alcohol or Odorless air. We measured the speed of male face recognition (implicit priming task) and collected ratings of facial attractiveness and likeability of men (explicit task). Only about half of the women tested were sensitive to Hedione. Those women did not show any effect of Hedione exposure in the implicit priming task and moderate, but non-significant effects in the explicit task. We therefore assume that Hedione is not a potent model of pheromone in humans and this observation may be due to the fact that the artificially produced substance is not suited for signaling the proximity of other humans. Furthermore, the high rate of Hedione-specific anosmia leads to the hypothesis that a substantial proportion of individuals has a poor V1NR1 receptor expression. © 2021 The Author(s)