Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2016
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| Subjects: | |
| Online Access: | View Fulltext in Publisher View in Scopus |
| LEADER | 02850nam a2200625Ia 4500 | ||
|---|---|---|---|
| 001 | 10.1016-j.phytol.2016.04.013 | ||
| 008 | 220120s2016 CNT 000 0 und d | ||
| 020 | |a 18743900 (ISSN) | ||
| 245 | 1 | 0 | |a Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra |
| 260 | 0 | |b Elsevier Ltd |c 2016 | |
| 520 | 3 | |a Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays. © 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. | |
| 650 | 0 | 4 | |a 24 methylenelanosta 7,9 diene 3beta 15 alpha diol |
| 650 | 0 | 4 | |a acetylcholinesterase |
| 650 | 0 | 4 | |a Acetylcholinesterase |
| 650 | 0 | 4 | |a alkaloid derivative |
| 650 | 0 | 4 | |a Anti-inflammatory |
| 650 | 0 | 4 | |a antiinflammatory activity |
| 650 | 0 | 4 | |a antiinflammatory agent |
| 650 | 0 | 4 | |a Article |
| 650 | 0 | 4 | |a ascorbic acid |
| 650 | 0 | 4 | |a bark |
| 650 | 0 | 4 | |a beilschglabrine A |
| 650 | 0 | 4 | |a beilschglabrine B |
| 650 | 0 | 4 | |a Beilschmiedia glabra |
| 650 | 0 | 4 | |a controlled study |
| 650 | 0 | 4 | |a DPPH radical scavenging activity |
| 650 | 0 | 4 | |a DPPH radical scavenging assay |
| 650 | 0 | 4 | |a drug identification |
| 650 | 0 | 4 | |a drug isolation |
| 650 | 0 | 4 | |a enzyme inhibition |
| 650 | 0 | 4 | |a enzyme inhibitor |
| 650 | 0 | 4 | |a galantamine |
| 650 | 0 | 4 | |a Lauraceae |
| 650 | 0 | 4 | |a lipoxygenase |
| 650 | 0 | 4 | |a lupeol |
| 650 | 0 | 4 | |a nonhuman |
| 650 | 0 | 4 | |a nuclear Overhauser effect |
| 650 | 0 | 4 | |a Phenanthrene alkaloid |
| 650 | 0 | 4 | |a phenanthrene derivative |
| 650 | 0 | 4 | |a priority journal |
| 650 | 0 | 4 | |a proton nuclear magnetic resonance |
| 650 | 0 | 4 | |a quercetin |
| 650 | 0 | 4 | |a taraxerol |
| 650 | 0 | 4 | |a unclassified drug |
| 700 | 1 | 0 | |a Ahmad, F. |e author |
| 700 | 1 | 0 | |a Chen, J.-J. |e author |
| 700 | 1 | 0 | |a Khong, H.Y. |e author |
| 700 | 1 | 0 | |a Nahar, L. |e author |
| 700 | 1 | 0 | |a Salleh, W.M.N.H.W. |e author |
| 700 | 1 | 0 | |a Sarker, S.D. |e author |
| 700 | 1 | 0 | |a Wansi, J.D. |e author |
| 700 | 1 | 0 | |a Zulkifli, R.M. |e author |
| 773 | |t Phytochemistry Letters |x 18743900 (ISSN) |g 16, 192-196 | ||
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.1016/j.phytol.2016.04.013 | ||
| 856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799 | ||