Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice

Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice

Receptor-interacting protein kinase 3 (Ripk3) is one of the critical mediators of inflammatory cytokine-stimulated signaling. Here we show that Ripk3 signaling selectively regulates both the number and the function of hematopoietic stem cells (HSCs) during stress conditions. Ripk3 signaling is not r...

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Bibliographic Details
Main Authors: Breslin, P.S.J (Author), Denning, M.F (Author), Ding, W.-X (Author), Huang, S. (Author), Liu, S. (Author), Luo, H. (Author), Ni, H.-M (Author), Sellin, M. (Author), Small, W., Jr (Author), Wei, W. (Author), Xing, H. (Author), Zhang, J. (Author), Zhang, L. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
HSCs
ionizing radiation
leukemia
Mlkl
necroptosis
Ripk3
Online Access:View Fulltext in Publisher

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