Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis

Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis

Malignant melanoma is a highly aggressive, malignant, and drug-resistant tumor. It lacks an efficient treatment approach. In this study, we developed a novel anti-melanoma strategy by using anti-tapeworm drug niclosamide and anti-malarial drug quinacrine, and investigated the molecular mechanism by...

Full description

Bibliographic Details
Main Authors: Ding, C. (Author), Dong, L. (Author), Gao, X. (Author), Li, S. (Author), Ma, Z. (Author), Sun, L. (Author), Wang, M. (Author), Wang, Y. (Author), Zhang, J. (Author), Zhang, Y. (Author), Zhao, N. (Author), Zheng, X. (Author)
Format: Article
Language:English
Published: Neoplasia Press, Inc. 2022
Subjects:
Apoptosis
Autophagy
Melanoma
Niclosamide
Quinacrine
Online Access:View Fulltext in Publisher

Similar Items

Similar Items