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01820nam a2200253Ia 4500 |
| 001 |
10.1016-j.ynstr.2022.100448 |
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220706s2022 CNT 000 0 und d |
| 020 |
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|a 23522895 (ISSN)
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| 245 |
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|a The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli
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| 260 |
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|b Elsevier Inc.
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1016/j.ynstr.2022.100448
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|a Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor gene polymorphism has been postulated as a potential sex-specific diagnostic biomarker of trauma-related disorders. However, no research to date has evaluated whether the PACAPergic system may act as a vulnerability/resilience neuromechanism to trauma-induced psychopathology in healthy participants without heightened risk to experience traumatic events. Methods: Here, we compared the amygdala and hippocampus response to fearful faces in participants with at-risk genotype versus non-risk participants from the Human Connectome Project (n = 991; 53.4% female). Results: Increased hippocampal response to fearful faces in the female risk group emerged in sex by genetic risk interaction. Conclusions: Our findings revealed the first sex-specific neurogenetic vulnerability factor to trauma-related disorders, and emphasize the importance of prevention-based strategies to ameliorate neuropsychiatric pathophysiology. © 2022 The Authors
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|a fMRI
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|a Hippocampus
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|a PACAP
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|a PTSD
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|a Threat
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|a Women
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|a Andero, R.
|e author
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|a Cano, M.
|e author
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|a Cardoner, N.
|e author
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|a Porta-Casteràs, D.
|e author
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|a Steward, T.
|e author
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| 773 |
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|t Neurobiology of Stress
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