Bactericidal Capacity of a Heterogeneous TiO2/ZnO Nanocomposite against Multidrug-Resistant and Non-Multidrug-Resistant Bacterial Strains Associated with Nosocomial Infections
The surge of medical devices associated with nosocomial infection (NI) cases, especially by multidrug-resistant (MDR) bacterial strains, is one of the pressing issues of present health care systems. Metal oxide nanoparticles (MNPs) have become promising antibacterial agents against a wide range of b...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
American Chemical Society,
2020
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Online Access: | View Fulltext in Publisher View in Scopus |
LEADER | 02461nam a2200229Ia 4500 | ||
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001 | 10.1021-acsomega.0c00213 | ||
008 | 220121s2020 CNT 000 0 und d | ||
020 | |a 24701343 (ISSN) | ||
245 | 1 | 0 | |a Bactericidal Capacity of a Heterogeneous TiO2/ZnO Nanocomposite against Multidrug-Resistant and Non-Multidrug-Resistant Bacterial Strains Associated with Nosocomial Infections |
260 | 0 | |b American Chemical Society, |c 2020 | |
856 | |z View Fulltext in Publisher |u https://doi.org/10.1021/acsomega.0c00213 | ||
856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085756624&doi=10.1021%2facsomega.0c00213&partnerID=40&md5=fda62e89d7c21065b6ebc3cf2628f7b3 | ||
520 | 3 | |a The surge of medical devices associated with nosocomial infection (NI) cases, especially by multidrug-resistant (MDR) bacterial strains, is one of the pressing issues of present health care systems. Metal oxide nanoparticles (MNPs) have become promising antibacterial agents against a wide range of bacterial strains. This work study is on the bactericidal capacity of heterogeneous TiO2/ZnO nanocomposites with different weight percentages and concentrations against common MDR and non-MDR bacterial strains. The profiles on disk diffusion, minimum inhibitory concentration, minimum bactericidal concentration, tolerance determination, time-kill, and biofilm inhibition assay were determined after 24 h of direct contact with the nanocomposite samples. Findings from this work revealed that the heterogeneous TiO2/ZnO nanocomposite with a 25T75Z weight ratio showed an optimal tolerance ratio against Gram-positive and-negative bacteria, indicating their bactericidal capacity. Further observation suggests that higher molar ratio of Zn2+ may possibly involve generation of active ion species that enhance bactericidal effect against Gram-positive bacterial strains, especially for the MDR strains. Nano-based technology using MNPs may provide a promising solution for the prevention and control of NIs. Further work on biocompatibility and cytotoxicity profiles of this nanocomposite are needed. © 2020 American Chemical Society. | |
700 | 1 | 0 | |a Aris, F. |e author |
700 | 1 | 0 | |a Basiron, N. |e author |
700 | 1 | 0 | |a Harun, N.H. |e author |
700 | 1 | 0 | |a Mydin, R.B.S.M.N. |e author |
700 | 1 | 0 | |a Saharudin, K.A. |e author |
700 | 1 | 0 | |a Seeni, A. |e author |
700 | 1 | 0 | |a Sreekantan, S. |e author |
700 | 1 | 0 | |a Zain, W.N.W.M. |e author |
773 | |t ACS Omega |x 24701343 (ISSN) |g 5 21, 12027-12034 |