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02612nam a2200469Ia 4500 |
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10.1038-s41467-022-29886-1 |
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220706s2022 CNT 000 0 und d |
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|a 20411723 (ISSN)
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| 245 |
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|a Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex
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| 260 |
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|b NLM (Medline)
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1038/s41467-022-29886-1
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|a Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition. © 2022. The Author(s).
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|a article
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|a association cortex
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|a autobiographical memory
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|a brain cortex
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|a cognition
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|a genetic regulation
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|a human
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|a human experiment
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|a Macaca
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|a meta analysis
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|a nonhuman
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|a social cognition
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|a structure activity relation
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|a writing
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|a Bayrak, Ş.
|e author
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|a Bernhardt, B.C.
|e author
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|a Bethlehem, R.A.I.
|e author
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|a Eickhoff, S.B.
|e author
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|a Kochunov, P.
|e author
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|a Margulies, D.
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|a Masouleh, S.K.
|e author
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|a Paquola, C.
|e author
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|a Park, B.-Y.
|e author
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|a Royer, J.
|e author
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|a Smallwood, J.
|e author
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|a Valk, S.L.
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|a Vos de Wael, R.
|e author
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|a Xu, T.
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|a Yeo, B.T.T.
|e author
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| 773 |
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|t Nature communications
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