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01908nam a2200301Ia 4500 |
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10.1038-s41467-022-29999-7 |
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|a 20411723 (ISSN)
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|a ON/OFF domains shape receptive field structure in mouse visual cortex
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|b Nature Research
|c 2022
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|z View Fulltext in Publisher
|u https://doi.org/10.1038/s41467-022-29999-7
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|a In higher mammals, thalamic afferents to primary visual cortex (area V1) segregate according to their responses to increases (ON) or decreases (OFF) in luminance. This organization induces columnar, ON/OFF domains postulated to provide a scaffold for the emergence of orientation tuning. To further test this idea, we asked whether ON/OFF domains exist in mouse V1. Here we show that mouse V1 is indeed parceled into ON/OFF domains. Interestingly, fluctuations in the relative density of ON/OFF neurons on the cortical surface mirror fluctuations in the relative density of ON/OFF receptive field centers on the visual field. Moreover, the local diversity of cortical receptive fields is explained by a model in which neurons linearly combine a small number of ON and OFF signals available in their cortical neighborhoods. These findings suggest that ON/OFF domains originate in fluctuations of the balance between ON/OFF responses across the visual field which, in turn, shapes the structure of cortical receptive fields. © 2022, The Author(s).
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|a animal experiment
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|a article
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|a controlled study
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|a male
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|a mouse
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|a neighborhood
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|a nerve cell
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|a nonhuman
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|a receptive field
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|a relative density
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|a visual cortex
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|a visual field
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|a Duan, K.K.
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|a Ringach, D.L.
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|a Tring, E.
|e author
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|t Nature Communications
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