IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

IRF4 is a master regulator of immunity and is also frequently overexpressed in mature lymphoid neoplasms. Here, we demonstrate the oncogenicity of IRF4 in vivo, its potential effects on T-cell development and clonal evolution using a zebrafish model. IRF4-transgenic zebrafish develop aggressive tumo...

Full description

Bibliographic Details
Main Authors: Ali, M.Z (Author), Amanda, S. (Author), Foo, E.Y (Author), Gong, Z. (Author), Huang, X.Z (Author), Iida, S. (Author), Inagaki, H. (Author), Li, Y. (Author), Ong, J.Z.L (Author), Pang, B. (Author), Sanda, T. (Author), Tan, S.Y (Author), Tan, T.K (Author), Theardy, M.S (Author), Wong, R.W.J (Author)
Format: Article
Language:English
Published: Nature Research 2022
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items