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02109nam a2200229Ia 4500 |
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10.1038-s41598-022-14553-8 |
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220718s2022 CNT 000 0 und d |
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|a 20452322 (ISSN)
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|a The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C
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|b Nature Research
|c 2022
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|z View Fulltext in Publisher
|u https://doi.org/10.1038/s41598-022-14553-8
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|a At present, noninvasive fibrosis markers are not available for the assessment of liver fibrosis in children with chronic hepatitis C. Sixty-three children with chronic hepatitis C were included. Changes in Wisteria floribunda agglutinin-positive Mac-2 binding protein (M2BPGi) levels were evaluated in l3 of 27 treatment-naive patients during the natural course of disease (median 4, range 3–6 years). Changes during treatment were evaluated in 27 of 36 patients for 4 (2–9) years of posttreatment follow-up. There were significant differences in the levels of M2BPGi between control group and HCV F0 group (P = 0.002) and between control group and HCV F1 group (P < 0.001). Receiver operating characteristic curve analysis showed that to discriminate stage F1 fibrosis from F0, the cut-off value was 0.95 for M2BPGi with a sensitivity of 52%, specificity of 90%, and area under the curve of 0.687. A substantial decrease in M2BPGi levels by treatment was shown from 0.98 ± 0.57 at pretreatment to 0.42 ± 0.15 at posttreatment (P < 0.001) in the 27 treated patients. Our study shows new findings that M2BPGi may be useful to predict the presence of a mild degree of fibrosis in children with chronic hepatitis C, and such mild fibrosis may be quickly resolved by treatment. © 2022, The Author(s).
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|a Bessho, K.
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|a Brooks, S.
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|a Hatori, R.
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|a Ito, Y.
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|a Miyoshi, Y.
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|a Murakami, J.
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|a Suzuki, M.
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|a Tajiri, H.
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|a Takano, T.
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|t Scientific Reports
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