Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications

Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications

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The syntheses of fourteen unusual o-carboxamido stilbenes by the Heck protocol revealed surprising complexity related to intriguing substituent effects with mechanistic implications. The unexpected cytotoxic and chemopreventive properties also seem to be substituent dependent. For example, although...

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Bibliographic Details
Main Authors: Ariffin, A. (Author), Awang, K. (Author), Chan, K.M (Author), Hussain, S.I (Author), Kee, C.H (Author), Lim, C.G (Author), Morita, H. (Author), Ng, S. (Author), Takeya, K. (Author), Thomas, N.F (Author), Threadgill, M.D (Author), Weber, J.F.F (Author), Wood, P.J (Author)
Format: Article
Language:English
Subjects:
amide
Amides
antineoplastic agent
Antineoplastic Agents
article
catalysis
Catalysis
cell line
Cell Line
cell strain HT29
cell survival
Cell Survival
chemistry
Chemopreventive
Chemopreventive activity
Colon cancer cells
Cytotoxic
Cytotoxicity
drug effect
Gold standards
Hepatocytes
HT29 Cells
human
Humans
Methoxy
oxidation reduction reaction
Oxidation-Reduction
palladium
Palladium
Resveratrol
stilbene derivative
Stilbenes
structure activity relation
Structure-Activity Relationship
Substituent effect
synthesis
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