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01937nam a2200325Ia 4500 |
| 001 |
10.1063-10.0009735 |
| 008 |
220510s2022 CNT 000 0 und d |
| 020 |
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|a 1063777X (ISSN)
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| 245 |
1 |
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|a Conformation impact in the deformation of DNA TATA-box
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| 260 |
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|b American Institute of Physics Inc.
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1063/10.0009735
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|a The ability to undergo specific deformation in response to conformational changes of some sites of the macromolecule is the key element of DNA genetic activity regulation in biological cells. The deformation of the definite sequences in DNA chain provides an accurate reading of genetic information and the process of protein synthesis passing. The model based on the analysis of conformational changes of the TATA nucleotide sequence in DNA double helix is developed. In addition to elastic components (bending, twisting), the presented model includes the conformational rearrangements of the TATA-box. Obtained form, value, and energy of DNA cite deformation allow to offer the probable mechanism of recognition of key DNA sequences and makes it possible to explain the high accuracy of the processes of reproducing of genetic information in biological cells. The formulated physical mechanism of DNA deformation can be one of the main principles of genetic information realization. © 2022 Author(s).
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|a Activity regulation
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|a Biological cells
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|a Biosynthesis
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|a Conformational change
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|a Deformation
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|a DNA
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|a DNA chains
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|a DNA sequences
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|a Genes
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|a Genetic activity
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|a Genetic information
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|a Key elements
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|a Model-based OPC
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|a Protein synthesis
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|a TATA box
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| 700 |
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|a Kanevska, P.P.
|e author
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| 700 |
1 |
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|a Volkov, S.N.
|e author
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| 773 |
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|t Low Temperature Physics
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