Biosynthesized gold nanoparticles-doped hydroxyapatite as antibacterial and antioxidant nanocomposite
A composite of hydroxyapatite (HA) doped with green synthesized gold nanoparticles (Au NPs) was prepared. Au NPs were produced via the bioreduction of HAuCl4 with Clitoria ternatea flower extract and utilized in HA synthesis, using Ca(OH)2 and ammonium diphosphate as precursors. The aim of this rese...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
IOP Publishing Ltd
2021
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Series: | Materials Research Express
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Subjects: | |
Online Access: | View Fulltext in Publisher View in Scopus |
LEADER | 03467nam a2200601Ia 4500 | ||
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001 | 10.1088-2053-1591-ac3309 | ||
008 | 220121s2021 CNT 000 0 und d | ||
020 | |a 20531591 (ISSN) | ||
245 | 1 | 0 | |a Biosynthesized gold nanoparticles-doped hydroxyapatite as antibacterial and antioxidant nanocomposite |
260 | 0 | |b IOP Publishing Ltd |c 2021 | |
490 | 1 | |a Materials Research Express | |
650 | 0 | 4 | |a Antibacterial |
650 | 0 | 4 | |a Anti-bacterial activity |
650 | 0 | 4 | |a Antibacterials |
650 | 0 | 4 | |a Antioxidant |
650 | 0 | 4 | |a Antioxidant activities |
650 | 0 | 4 | |a Antioxidants |
650 | 0 | 4 | |a Au nanoparticle |
650 | 0 | 4 | |a Au nanoparticles |
650 | 0 | 4 | |a Bioreductions |
650 | 0 | 4 | |a Chlorine compounds |
650 | 0 | 4 | |a Clitoria ternatea |
650 | 0 | 4 | |a Doped hydroxyapatites |
650 | 0 | 4 | |a Escherichia coli |
650 | 0 | 4 | |a Fiber optic sensors |
650 | 0 | 4 | |a Flower extracts |
650 | 0 | 4 | |a Gold compounds |
650 | 0 | 4 | |a Gold nanoparticles |
650 | 0 | 4 | |a Green synthesis |
650 | 0 | 4 | |a High resolution transmission electron microscopy |
650 | 0 | 4 | |a Hydrated lime |
650 | 0 | 4 | |a Hydroxyapatite |
650 | 0 | 4 | |a Metal nanoparticles |
650 | 0 | 4 | |a Nanocomposites |
650 | 0 | 4 | |a Particle size |
650 | 0 | 4 | |a Particle size analysis |
650 | 0 | 4 | |a Scanning electron microscopy |
650 | 0 | 4 | |a Synthesis (chemical) |
650 | 0 | 4 | |a Synthesised |
650 | 0 | 4 | |a Ultraviolet visible spectroscopy |
856 | |z View Fulltext in Publisher |u https://doi.org/10.1088/2053-1591/ac3309 | ||
856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119356101&doi=10.1088%2f2053-1591%2fac3309&partnerID=40&md5=be2fe7e896fa16c4fd39eb450d4338ef | ||
520 | 3 | |a A composite of hydroxyapatite (HA) doped with green synthesized gold nanoparticles (Au NPs) was prepared. Au NPs were produced via the bioreduction of HAuCl4 with Clitoria ternatea flower extract and utilized in HA synthesis, using Ca(OH)2 and ammonium diphosphate as precursors. The aim of this research was to analyze the structure of the composite and conduct an antibacterial activity test involving Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Streptococcus pyogenes. In addition, antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl radical scavenging. Au NP formation monitoring was conducted by UV-visible spectroscopy and particle size analysis, and the synthesized composite was studied using X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The results revealed homogeneously dispersed Au NPs (particle size ranging from 5 to 80 nm) in the HA structure. The nanocomposite demonstrated enhanced antibacterial activity against the tested bacteria compared to HA, with minimum inhibition concentrations of 3 μg ml−1 for E.coli and S.aureus and 10 μg ml−1 for K. pneumoniae and S. pyogenes. The nanocomposite expressed antioxidant activity, as shown by 2,2-diphenyl-1-picrylhydrazyl scavenging activities of 66% and 58% at concentrations of 100 μg ml−1 and 50 μg ml−1, respectively. © 2021 The Author(s). Published by IOP Publishing Ltd | |
700 | 1 | 0 | |a Citradewi, P.W. |e author |
700 | 1 | 0 | |a Fatimah, I. |e author |
700 | 1 | 0 | |a Ghazali, S.A.I.S.M. |e author |
700 | 1 | 0 | |a Hidayat, H. |e author |
700 | 1 | 0 | |a Ibrahim, S. |e author |
700 | 1 | 0 | |a Nugroho, B.H. |e author |
700 | 1 | 0 | |a Purwiandono, G. |e author |
700 | 1 | 0 | |a Sagadevan, S. |e author |
700 | 1 | 0 | |a Yahya, A. |e author |
773 | |t Materials Research Express |