Critical parameters for particle-based pulmonary delivery of chemotherapeutics

Critical parameters for particle-based pulmonary delivery of chemotherapeutics

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Targeted delivery of chemotherapeutics through the respiratory system is a potential approach to improve drug accumulation in the lung tumor, while decreasing their negative side effects. However, elimination by the pulmonary clearance mechanisms, including the mucociliary transport system, and inge...

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Bibliographic Details
Main Authors: Abdul Rahman, N. (Author), Abu Kasim, N.H (Author), Dabbagh, A. (Author), Wong, T.W (Author), Yeong, C.H (Author)
Format: Article
Language:English
Published: Mary Ann Liebert Inc. 2018
Subjects:
aerosol
Aerosols
antineoplastic agent
azacitidine
camptothecin
cancer chemotherapy
cancer classification
cancer staging
carboplatin
chemical composition
Chemotherapeutics
cisplatin
Clearance
clinical outcome
docetaxel
doxorubicin
drug carrier
Drug Carriers
drug delivery system
Drug Delivery Systems
dry powder inhaler
Dry Powder Inhalers
etoposide
fluorouracil
gelatin
gemcitabine
glucose
human
Humans
ifosfamide
lactose
ligand
ligand binding
lung
Lung
lung cancer
lung metastasis
Lung Neoplasms
lung tumor
mannitol
metabolism
mitomycin
nanocarrier
nanoparticle
non small cell lung cancer
nonhuman
osteosarcoma
oxaliplatin
paclitaxel
particle based pulmonary delivery system
particle size
Particle Size
Particles
pemetrexed
pharmacological parameters
physical chemistry
polymer
Pulmonary drug delivery systems
Review
small cell lung cancer
solid lipid nanoparticle
sorbitol
surface property
unindexed drug
vinblastine
vindesine
vinorelbine tartrate
xylitol
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