Iodine allergy: Common misperceptions

Purpose: The current evidence regarding iodine-containing compounds and iodine allergy cross-reactivity is reviewed. Summary: Iodine is an essential human nutrient found in the thyroid gland. It is used in the synthesis of the thyroid hormones thyroxine and triiodothyroxine. Patients who report havi...

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Bibliographic Details
Main Authors: Choi, A. (Author), Kapusnik-Uner, J. (Author), Schmitz, J. (Author), Wulf, N.R (Author)
Format: Article
Language:English
Published: Oxford University Press 2021
Subjects:
Online Access:View Fulltext in Publisher
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020 |a 10792082 (ISSN) 
245 1 0 |a Iodine allergy: Common misperceptions 
260 0 |b Oxford University Press  |c 2021 
856 |z View Fulltext in Publisher  |u https://doi.org/10.1093/ajhp/zxab033 
520 3 |a Purpose: The current evidence regarding iodine-containing compounds and iodine allergy cross-reactivity is reviewed. Summary: Iodine is an essential human nutrient found in the thyroid gland. It is used in the synthesis of the thyroid hormones thyroxine and triiodothyroxine. Patients who report having adverse reactions to iodine-containing substances are often labelled as having an "iodine allergy,"which can result in delays in care or patients being denied essential iodinated contrast media (ICM) or other iodine-containing drugs. A literature review was conducted to evaluate the evidence regarding iodine allergy and iodine-containing drugs. Of 435 articles considered potentially appropriate for full review (plus 12 additional articles included on the basis of references from the eligible articles), 113 could not be obtained. After exclusion of 353 articles that did not meet all inclusion criteria, the remaining 81 articles were included in the review. The results of the literature review indicated that iodine has not been shown to be the allergen responsible for allergic reactions to iodinated contrast media, amiodarone, povidone-iodine, and other iodine-containing compounds. Conclusion: There is a lack of evidence to support cross-reactivity between iodine-containing compounds in so called iodine-allergic individuals. © 2021 
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700 1 |a Choi, A.  |e author 
700 1 |a Kapusnik-Uner, J.  |e author 
700 1 |a Schmitz, J.  |e author 
700 1 |a Wulf, N.R.  |e author 
773 |t American Journal of Health-System Pharmacy