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| LEADER |
01469nam a2200169Ia 4500 |
| 001 |
10.1093-bioinformatics-btab449 |
| 008 |
220427s2021 CNT 000 0 und d |
| 020 |
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|a 13674803 (ISSN)
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| 245 |
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|a Cheetah-MS: A web server to model protein complexes using tandem cross-linking mass spectrometry data
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| 260 |
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|b Oxford University Press
|c 2021
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1093/bioinformatics/btab449
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| 520 |
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|a Summary: Protein-protein interactions (PPIs) are central in many biological processes but difficult to characterize, especially in complex, unfractionated samples. Chemical cross-linking combined with mass spectrometry (MS) and computational modeling is gaining recognition as a viable tool in protein interaction studies. Here, we introduce Cheetah-MS, a web server for predicting the PPIs in a complex mixture of samples. It combines the capability and sensitivity of MS to analyze complex samples with the power and resolution of protein-protein docking. It produces the quaternary structure of the PPI of interest by analyzing tandem MS/MS data (also called MS2). Combining MS analysis and modeling increases the sensitivity and, importantly, facilitates the interpretation of the results. © 2021 The Author(s) 2021. Published by Oxford University Press.
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| 700 |
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|a Happonen, L.
|e author
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| 700 |
1 |
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|a Khakzad, H.
|e author
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| 700 |
1 |
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|a Malmström, J.
|e author
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| 700 |
1 |
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|a Malmström, L.
|e author
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| 773 |
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|t Bioinformatics
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