PathwAX II: Network-based pathway analysis with interactive visualization of network crosstalk
Motivation: Pathway annotation tools are indispensable for the interpretation of a wide range of experiments in life sciences. Network-based algorithms have recently been developed which are more sensitive than traditional overlap-based algorithms, but there is still a lack of good online tools for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |
| Summary: | Motivation: Pathway annotation tools are indispensable for the interpretation of a wide range of experiments in life sciences. Network-based algorithms have recently been developed which are more sensitive than traditional overlap-based algorithms, but there is still a lack of good online tools for network-based pathway analysis. Results: We present PathwAX II- A pathway analysis web tool based on network crosstalk analysis using the BinoX algorithm. It offers several new features compared with the first version, including interactive graphical network visualization of the crosstalk between a query gene set and an enriched pathway, and the addition of Reactome pathways. © 2022 The Author(s). Published by Oxford University Press. |
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| ISBN: | 13674803 (ISSN) |
| DOI: | 10.1093/bioinformatics/btac153 |