PathwAX II: Network-based pathway analysis with interactive visualization of network crosstalk

Motivation: Pathway annotation tools are indispensable for the interpretation of a wide range of experiments in life sciences. Network-based algorithms have recently been developed which are more sensitive than traditional overlap-based algorithms, but there is still a lack of good online tools for...

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Bibliographic Details
Main Authors: Castresana-Aguirre, M. (Author), Ogris, C. (Author), Sonnhammer, E.L.L (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Subjects:
Online Access:View Fulltext in Publisher
LEADER 01396nam a2200193Ia 4500
001 10.1093-bioinformatics-btac153
008 220706s2022 CNT 000 0 und d
020 |a 13674803 (ISSN) 
245 1 0 |a PathwAX II: Network-based pathway analysis with interactive visualization of network crosstalk 
260 0 |b Oxford University Press  |c 2022 
856 |z View Fulltext in Publisher  |u https://doi.org/10.1093/bioinformatics/btac153 
520 3 |a Motivation: Pathway annotation tools are indispensable for the interpretation of a wide range of experiments in life sciences. Network-based algorithms have recently been developed which are more sensitive than traditional overlap-based algorithms, but there is still a lack of good online tools for network-based pathway analysis. Results: We present PathwAX II- A pathway analysis web tool based on network crosstalk analysis using the BinoX algorithm. It offers several new features compared with the first version, including interactive graphical network visualization of the crosstalk between a query gene set and an enriched pathway, and the addition of Reactome pathways. © 2022 The Author(s). Published by Oxford University Press. 
650 0 4 |a algorithm 
650 0 4 |a article 
650 0 4 |a pathway analysis 
700 1 |a Castresana-Aguirre, M.  |e author 
700 1 |a Ogris, C.  |e author 
700 1 |a Sonnhammer, E.L.L.  |e author 
773 |t Bioinformatics