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10.1101-lm.047399.118 |
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220706s2018 CNT 000 0 und d |
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|a 10720502 (ISSN)
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|a A principled method to identify individual differences and behavioral shifts in signaled active avoidance
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|b Cold Spring Harbor Laboratory Press
|c 2018
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|z View Fulltext in Publisher
|u https://doi.org/10.1101/lm.047399.118
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|a Signaled active avoidance (SigAA) is the key experimental procedure for studying the acquisition of instrumental responses toward conditioned threat cues. Traditional analytic approaches (e.g., general linear model) often obfuscate important individual differences, although individual differences in learned responses characterize both animal and human learning data. However, individual differences models (e.g., latent growth curve modeling) typically require large samples and onerous computational methods. Here, we present an analytic methodology that enables the detection of individual differences in SigAA performance at a high accuracy, even when a single animal is included in the data set (i.e., n = 1 level). We further show an online software that enables the easy application of our method to any SigAA data set. © 2018 Krypotos et al.
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|a accuracy
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|a animal
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|a Animals
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|a Article
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|a avoidance behavior
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|a Avoidance Learning
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|a conditioning
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|a Conditioning (Psychology)
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|a Data Interpretation, Statistical
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|a individuality
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|a Individuality
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|a learning
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|a male
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|a Male
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|a methodology
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|a Models, Statistical
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|a nonhuman
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|a performance
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|a priority journal
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|a psychologic test
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|a Psychological Tests
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|a Rats, Sprague-Dawley
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|a reaction time
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|a Reaction Time
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|a reproducibility
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|a Reproducibility of Results
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|a signaled active avoidance
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|a software
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|a Software
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|a Sprague Dawley rat
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|a statistical analysis
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|a statistical model
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|a threat
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|a Galatzer-Levy, I.
|e author
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|a Krypotos, A.-M.
|e author
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|a LeDoux, J.E.
|e author
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|a Moscarello, J.M.
|e author
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|a Sears, R.M.
|e author
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|t Learning and Memory
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