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03843nam a2200769Ia 4500 |
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10.1111-cdoe.12414 |
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220706s2018 CNT 000 0 und d |
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|a 03015661 (ISSN)
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|a Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study
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|b Blackwell Munksgaard
|c 2018
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|z View Fulltext in Publisher
|u https://doi.org/10.1111/cdoe.12414
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|a Objectives: To examine associations between periodontitis at ages 32 and 38 and a range of early cardiometabolic risk biomarkers at age 38. Methods: Periodontal probing depth and bleeding on probing data collected during the age-32 and age-38 assessments in the Dunedin Multidisciplinary Health and Development Study were used to quantify periodontal inflammatory load. Retinal microvascular abnormalities, endothelial dysfunction, and metabolic syndrome data were collected during the age-38 assessment. Regression models were used to examine associations between these cardiometabolic risk markers and (1) the inflammatory load at age 38 and (2) the change in inflammatory load between ages 32 and 38. Results: Periodontal inflammatory load was recorded for 890 Study members at age 32, 891 at age 38, and 856 at both ages. Retinal vessel data were available for 922, endothelial dysfunction data for 909 and metabolic syndrome data for 905 at age 38. Neither the inflammatory load of periodontitis at 38 nor the changes in inflammatory load 32-38 were found to be associated with any of the three cardiometabolic risk markers. Conclusions: Periodontitis was not associated with markers of cardiometabolic risk at this relatively early stage in the life course. It is possible that any influence of periodontitis on cardiometabolic health develops later in life, or periodontitis is not involved in the putative causal chain comprising systemic inflammation, cardiometabolic risk markers, and subsequent cardiovascular risk. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
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|a adult
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|a Adult
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|a biological marker
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|a Biomarkers
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|a blood
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|a cardiometabolic
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|a cardiovascular disease
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|a Cardiovascular Diseases
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|a Cholesterol, HDL
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|a chronic periodontitis
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|a Chronic Periodontitis
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|a cohort analysis
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|a Cohort Studies
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|a complication
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|a endothelial dysfunction
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|a Endothelium, Vascular
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|a female
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|a Female
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|a Glycated Hemoglobin A
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|a glycosylated hemoglobin
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|a hemoglobin A1c protein, human
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|a high density lipoprotein cholesterol
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|a human
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|a Humans
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|a male
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|a Male
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|a metabolic syndrome
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|a Metabolic Syndrome
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|a metabolic syndrome X
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|a microcirculation
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|a New Zealand
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|a pathology
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|a periodontal index
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|a Periodontal Index
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|a periodontitis
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|a peripheral arterial tonometry
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|a retina blood vessel
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|a retinal vascular calibre
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|a Retinal Vessels
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|a risk factor
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|a Risk Factors
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|a triacylglycerol
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|a Triglycerides
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|a vascular endothelium
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|a Cameron, C.M.
|e author
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|a McLean, R.
|e author
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|a Poulton, R.
|e author
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|a Ramrakha, S.
|e author
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|a Shearer, D.M.
|e author
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|a Theodore, R.
|e author
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|a Thomson, W.M.
|e author
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|a Williams, M.J.A.
|e author
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|a Wilson, G.
|e author
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|a Wong, T.Y.
|e author
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|t Community Dentistry and Oral Epidemiology
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