Randomized controlled clinical study assessing two membranes for guided bone regeneration of peri-implant bone defects: 3-year results

• Main Authors: Basler, T. (Author), Hämmerle, C.H.F (Author), Jung, R.E (Author), Naenni, N. (Author), Schneider, D. (Author), Thoma, D.S (Author)
• Format: Article
• Language: English
• Published: Blackwell Munksgaard 2018
• Subjects: alveolar ridge augmentation; Alveolar Ridge Augmentation; bone prosthesis; Bone Substitutes; controlled study; Dental Implantation, Endosseous; dental implants; Dental Implants, Single-Tooth; drug therapy; female; Female; Guided Tissue Regeneration, Periodontal; human; Humans; male; Male; membranes; middle aged; Middle Aged; periodontal guided tissue regeneration; procedures; randomized controlled trial; single tooth implant; tooth implantation; volume stability; volumetric analysis
• Online Access: View Fulltext in Publisher

 Objectives: To assess two- and three-dimensional changes of the peri-implant tissues as well as clinical, biological, and radiological outcomes of implants having been treated with resorbable or nonresorbable membranes at 3 years. Materials and methods: Twenty-three patients were re-examined after having received a single-tooth implant in the esthetic zone in conjunction with guided bone regeneration (GBR) using either a resorbable (RES) or a titanium-reinforced nonresorbable membrane (N-RES) and demineralized bovine bone mineral. Volumetric and linear as well as clinical and radiographic measurements were performed at crown insertion (baseline), at 1 year (FU-1) and 3 years (FU-3). Statistics were performed by means of parametric and nonparametric tests. Results: Minor, but ongoing buccal volume loss was observed in both groups during the 3-year follow-up. A slightly higher volume loss was observed in group RES (−0.22 mm) compared to N-RES (−0.14 mm) at 1 year (FU-1), but aligned at 3 years (FU-3) RES (−0.30 mm) N-RES (−0.32 mm). All changes over time were statistically significantly different within (p <.05), but not between the groups (p >.05). Stable median interproximal bone levels after 3 years (FU-3); 0.26 mm (0.04; 0.36) (RES) and 0.14 mm (0.08; 0.20) (N-RES) and healthy tissues (BOP, PD) were obtained with both membranes. Conclusions: Both treatment modalities resulted in minor, but ongoing contour changes of the peri-implant tissues. Stable interproximal bone levels and healthy tissues can be obtained with membranes up to 3 years. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd