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| LEADER |
03298nam a2200685Ia 4500 |
| 001 |
10.1111-jop.12791 |
| 008 |
220427s2021 CNT 000 0 und d |
| 020 |
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|a 09042512 (ISSN)
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| 245 |
1 |
0 |
|a Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma: Systematic review and meta-analysis
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| 260 |
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0 |
|b Blackwell Publishing Ltd
|c 2021
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1111/jop.12791
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| 520 |
3 |
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|a Background: More than 90% of malignant tumors of the head and neck are oral squamous cell carcinomas. Early detection of oral squamous cell carcinoma using salivary biomarkers could prevent malignant transformations and enhance patient survival. Methods: A systematic search in MEDLINE and the Central Register of Controlled Trials and meta-analysis were undertaken to identify the screening potential of six salivary biomarkers for early oral squamous cell carcinoma detection: interleukins IL-8 and IL1-β, DUSP-1 and S100P messenger RNAs, and miR125a and miR200a microRNAs. Results: The sensitivities of IL-8 (0.41; 95%CI 0.19-0.99), IL1-β (0.26; 95%CI 0.19-0.99), DUSP-1 (0.61; 95%CI 0.01-0.98), and S100P (0.67; 95%CI 0.32-0.99) were calculated. Specificities of the biomarkers analyzed were found to be IL-8 (0.69; 95%CI 0.66-0.99), IL1-β (0.47; 95%CI 0.46-0.90), DUSP-1 (0.75; 95%CI 0.33-1), and S100P (0.73; 95%CI 0.18-0.99). Conclusions: Early detection of oral squamous cell carcinoma was best achieved by screening for salivary messenger RNA DUSP-1 and S100P. Further investigation is required into miRNAs as novel biomarkers. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
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|a adult
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|a Article
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|a biological marker
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| 650 |
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|a Biomarkers, Tumor
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| 650 |
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|a Carcinoma, Squamous Cell
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| 650 |
0 |
4 |
|a diagnostic accuracy
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| 650 |
0 |
4 |
|a enzyme linked immunosorbent assay
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| 650 |
0 |
4 |
|a female
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| 650 |
0 |
4 |
|a genetics
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| 650 |
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4 |
|a Head and Neck Neoplasms
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| 650 |
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|a head and neck squamous cell carcinoma
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| 650 |
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4 |
|a head and neck tumor
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| 650 |
0 |
4 |
|a human
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| 650 |
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4 |
|a Humans
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| 650 |
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4 |
|a interleukin 1beta
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| 650 |
0 |
4 |
|a interleukin 8
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| 650 |
0 |
4 |
|a male
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| 650 |
0 |
4 |
|a messenger RNA
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| 650 |
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4 |
|a meta analysis
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| 650 |
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4 |
|a microarray analysis
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| 650 |
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4 |
|a microRNA 125a
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| 650 |
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4 |
|a microRNA 200a
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| 650 |
0 |
4 |
|a middle aged
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| 650 |
0 |
4 |
|a mitogen activated protein kinase phosphatase 1
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| 650 |
0 |
4 |
|a Mouth Neoplasms
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| 650 |
0 |
4 |
|a mouth squamous cell carcinoma
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| 650 |
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4 |
|a mouth tumor
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| 650 |
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4 |
|a oral squamous cell carcinoma
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| 650 |
0 |
4 |
|a priority journal
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| 650 |
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|a protein S 100
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| 650 |
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4 |
|a real time polymerase chain reaction
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| 650 |
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|a RNA stability
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| 650 |
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4 |
|a s100 p protein
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| 650 |
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4 |
|a saliva
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| 650 |
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|a Saliva
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| 650 |
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|a salivary biomarkers
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| 650 |
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|a screening
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| 650 |
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|a sensitivity and specificity
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| 650 |
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4 |
|a squamous cell carcinoma
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| 650 |
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4 |
|a Squamous Cell Carcinoma of Head and Neck
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| 650 |
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|a systematic review
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| 650 |
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|a systematic review
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| 650 |
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|a tumor marker
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| 650 |
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4 |
|a unclassified drug
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| 700 |
1 |
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|a Gaba, F.I.
|e author
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1 |
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|a Sheth, C.C.
|e author
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| 700 |
1 |
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|a Veses, V.
|e author
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| 773 |
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|t Journal of Oral Pathology and Medicine
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