Prevalence and concordance of oral HPV infections with cervical HPV infections in women referred to colposcopy with abnormal cytology

• Main Authors: Banka, P. (Author), Comiskey, C. (Author), D’Arcy, T. (Author), Kernan, N. (Author), Martin, C.M (Author), Murphy, C. (Author), O’Leary, J.J (Author), O’Toole, S. (Author), Pilkington, L. (Author), Reynolds, S. (Author), Sharp, L. (Author), Tewari, P. (Author), White, C. (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; alcohol consumption; Article; cannabis use; cervical; Cervical Intraepithelial Neoplasia; colposcopy; Colposcopy; controlled study; cross-sectional study; employment status; female; Female; genetics; genotype; Genotype; human; human papilloma virus; human tissue; Humans; Ireland; loop electrosurgical excision; major clinical study; mouth infection; nonhuman; oral; Papillomaviridae; papillomavirus infection; Papillomavirus Infections; people by smoking status; pregnancy; Pregnancy; prevalence; Prevalence; punch biopsy; risk factor; sexual behavior; sexuality; Uterine Cervical Neoplasms; uterine cervicitis; uterine cervix biopsy; uterine cervix carcinoma in situ; uterine cervix cytology; uterine cervix tumor
• Online Access: View Fulltext in Publisher
• ISBN: 09042512 (ISSN)
• DOI: 10.1111/jop.13172

Background: Considering the shared aetiology of Human Papillomavirus infections in oropharyngeal and cervical cancers and the possible role for sexual transmission, several key aspects of the relationship between cervical and oral infections merit investigation, including prevalence of concomitant oral HPV infection and type-specific concordance with concurrent cervical infections. Methods: A cross-section study was performed on women referred to colposcopy clinics with cytological abnormalities and a cervical HPV infection. An oral rinse sample was taken from the participants at their baseline visit for HPV testing, and a demographic and risk factor questionnaire was also administered. HPV DNA testing was carried out on the Cobas 4800 platform and extended genotyping was carried out with the INNO-LiPA HPV Genotyping Extra II assay. HPV genotyping was also carried out on the concurrent cervical tissue samples on all women who had a positive oral HPV infection. Results: The prevalence of oral HPV infections was 10.0% (95%CI:5.9–13.7) in the study population. HPV18 was the most frequent genotype (7.0%). Concordant oral and cervical HPV infections were detected in 28.6% of women. Age (p = 0.005) and level of education (p = 0.02) were significantly associated with a prevalent oral HPV infection. Conclusion: Concomitant oral HPV infections were present in 10.0% of women referred to colposcopy with a pre-existing cervical HPV infections and cytological abnormalities. Although mild type-specific concordance was observed between oral and cervical HPV infections, findings suggest that infections at these sites may not be independent of each other. © 2021 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd.