Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge
Interleukin-11 (IL-11) is a profibrotic cytokine essential for the differentiation of fibroblasts into collagen-secreting, actin alpha 2, smooth muscle-positive (ACTA2+) myofibroblasts, driving processes underlying the pathogenesis of idiopathic pulmonary fibrosis (IPF). Here, we developed an inhala...
Main Authors: | Bai, X. (Author), Chen, Q. (Author), Gao, M. (Author), Ho, W. (Author), Li, Z. (Author), Xu, X. (Author), Zhang, X.-Q (Author), Zhao, G. (Author) |
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Format: | Article |
Language: | English |
Published: |
NLM (Medline)
2022
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Online Access: | View Fulltext in Publisher |
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