Asia-Pacific consensus statement on the optimal use of high-sensitivity troponin assays in acute coronary syndromes diagnosis: Focus on hs-TnI

• Main Authors: Abanilla, J.M (Author), Aw, T.C (Author), Chang, W.-T (Author), Cullen, L. (Author), Dang, V.P (Author), Iboleon-Dy, M. (Author), Kasim, S.S (Author), Lam, C.S.P (Author), Mumpuni, S.S (Author), Phommintikul, A. (Author), Ta, M.C (Author), Tan, J.W.C (Author), Topipat, P. (Author), Yiu, K.H (Author)
• Format: Article
• Language: English
• Published: BMJ Publishing Group 2017
• Subjects: acute coronary syndrome; acute heart infarction; Article; cardiac troponin 1 CLIA kit; diagnostic accuracy; differential diagnosis; echocardiography; electrocardiography; human; limit of detection; point of care testing; predictive value; sensitivity and specificity; sex difference; thorax pain; troponin I; troponin T
• Online Access: View Fulltext in Publisher; View in Scopus

 Objective High-sensitivity troponin (hs-Tn) assays need to be applied appropriately to improve diagnosis and patient outcomes in acute coronary syndromes (ACS). Methods Experts from Asia Pacific convened in 2015 to provide data-driven consensus-based, region-specific recommendations and develop an algorithm for the appropriate incorporation of this assay into the ACS assessment and treatment pathway. Results Nine recommendations were developed by the expert panel: (1) troponin is the preferred cardiac biomarker for diagnostic assessment of ACS and is indicated for patients with symptoms of possible ACS; (2) hs-Tn assays are recommended; (3) serial testing is required for all patients; (4) testing should be performed at presentation and 3 hours later; (5) gender-specific cut-off values should be used for hs-Tn I assays; (6) hs- Tn I level >10 times the upper limit of normal should be considered to rule in a diagnosis of ACS; (7) dynamic change >50% in hs-Tn I level from presentation to 3- hour retest identifies patients at high risk for ACS; (8) where only point-of-care testing is available, patients with elevated readings should be considered at high risk, while patients with low/undetectable readings should be retested after 6 hours or sent for laboratory testing and (9) regular education on the appropriate use of troponin tests is essential. Conclusions We propose an algorithm that will potentially reduce delays in discharge by the accurate rule out of non-ACS patients within 3 hours. Appropriate research should be undertaken to ensure the efficacy and safety of the algorithm in clinical practice, with the long-term goal of improvement of care of patients with ACS in Asia Pacific.