Antinociceptive and anti-inflammatory effects of stachytarpheta jamaicensis (L.) Vahl (Verbenaceae)in experimental animal models
Objective: The present study was carried out to explore the antinociceptive as well as the anti-inflammatory effects of an ethanol extract of Stachytarpheta jamaicensis (L.) Vahl (EESJ) using 3 models of nociception and 2 models of inflammation in experimental animals. Materials and Methods: EESJ wa...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
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Online Access: | View Fulltext in Publisher View in Scopus |
LEADER | 04339nam a2200793Ia 4500 | ||
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001 | 10.1159-000215723 | ||
008 | 220112s2009 CNT 000 0 und d | ||
020 | |a 10117571 (ISSN) | ||
245 | 1 | 0 | |a Antinociceptive and anti-inflammatory effects of stachytarpheta jamaicensis (L.) Vahl (Verbenaceae)in experimental animal models |
856 | |z View Fulltext in Publisher |u https://doi.org/10.1159/000215723 | ||
856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-67650264869&doi=10.1159%2f000215723&partnerID=40&md5=8aabf499e274645edb29b5c8db196904 | ||
520 | 3 | |a Objective: The present study was carried out to explore the antinociceptive as well as the anti-inflammatory effects of an ethanol extract of Stachytarpheta jamaicensis (L.) Vahl (EESJ) using 3 models of nociception and 2 models of inflammation in experimental animals. Materials and Methods: EESJ was prepared by overnight soaking of the oven-dried (50°C; 72 h) ground leaves (500 g) in 80% ethanol (1:5; w/v). The filtrate was evaporated to dryness (50°C), resuspended in distilled water at concentrations to provide the desired doses of 50, 100 and 150 mg/kg. For antinociceptive effects, 3 models were used: acetic acid-induced abdominal writhing, hot-plate- and formalin-induced paw-licking tests; for anti-inflammatory effects, 2 models were used - carrageenan-induced paw edema and cotton-pellet-induced granuloma tests. Appropriate doses were administered intraperitoneally (i.p.) to mice/rats prior to each test. The mechanisms of antinociceptive action of the extract were also investigated by pretreatment with naloxone (5 mg/kg, i.p.). Results: The extract exhibited significant (p < 0.05) antinociceptive activity in all nociceptive models tested with dose-dependent activity observed using the abdominal writhing and formalin tests. Pretreatment with naloxone partially, but significantly (p < 0.05) reversed the antinociceptive activity of the extract when assessed using the abdominal-writhing- and formalin-induced paw-licking tests, and completely inhibited its activity when the hot-plate test was used. The extract also showed significant (p < 0.05) anti-inflammatory activity in both the acute (carrageenan-induced paw edema test) and the chronic (cotton-pellet granuloma test) tests. Conclusion: This study showed the potential of EESJ to exert antinociceptive and anti-inflammatory activities, the former being modulated via peripheral and central mechanisms and involving, in part, activation of the opioid receptor system. Copyright © 2009 S. Karger AG, Basel. | |
650 | 0 | 4 | |a acetic acid |
650 | 0 | 4 | |a acetylsalicylic acid |
650 | 0 | 4 | |a Analgesics |
650 | 0 | 4 | |a animal experiment |
650 | 0 | 4 | |a animal model |
650 | 0 | 4 | |a animal tissue |
650 | 0 | 4 | |a Animals |
650 | 0 | 4 | |a antiinflammatory activity |
650 | 0 | 4 | |a Anti-inflammatory activity |
650 | 0 | 4 | |a Anti-Inflammatory Agents |
650 | 0 | 4 | |a antinociception |
650 | 0 | 4 | |a Antinociceptive activity |
650 | 0 | 4 | |a article |
650 | 0 | 4 | |a Aspirin |
650 | 0 | 4 | |a carrageenan |
650 | 0 | 4 | |a controlled study |
650 | 0 | 4 | |a dose response |
650 | 0 | 4 | |a drug dose comparison |
650 | 0 | 4 | |a drug mechanism |
650 | 0 | 4 | |a experimental test |
650 | 0 | 4 | |a formaldehyde |
650 | 0 | 4 | |a granuloma |
650 | 0 | 4 | |a hot plate test |
650 | 0 | 4 | |a male |
650 | 0 | 4 | |a Male |
650 | 0 | 4 | |a medicinal plant |
650 | 0 | 4 | |a Mice |
650 | 0 | 4 | |a Mice, Inbred BALB C |
650 | 0 | 4 | |a morphine |
650 | 0 | 4 | |a Morphine |
650 | 0 | 4 | |a mouse |
650 | 0 | 4 | |a naloxone |
650 | 0 | 4 | |a nonhuman |
650 | 0 | 4 | |a opiate receptor |
650 | 0 | 4 | |a Opioid mechanism |
650 | 0 | 4 | |a Pain Measurement |
650 | 0 | 4 | |a paw edema |
650 | 0 | 4 | |a paw licking test |
650 | 0 | 4 | |a Phytotherapy |
650 | 0 | 4 | |a plant extract |
650 | 0 | 4 | |a Plant Extracts |
650 | 0 | 4 | |a Plant Leaves |
650 | 0 | 4 | |a rat |
650 | 0 | 4 | |a Rats |
650 | 0 | 4 | |a Rats, Sprague-Dawley |
650 | 0 | 4 | |a Stachytarpheta jamaicensis |
650 | 0 | 4 | |a Stachytarpheta jamaicensis extract |
650 | 0 | 4 | |a unclassified drug |
650 | 0 | 4 | |a Verbenaceae |
650 | 0 | 4 | |a writhing test |
700 | 1 | 0 | |a Azam Shah, T.M. |e author |
700 | 1 | 0 | |a Chiong, H.S. |e author |
700 | 1 | 0 | |a Israf, D.A. |e author |
700 | 1 | 0 | |a Lai, S.K. |e author |
700 | 1 | 0 | |a Sulaiman, M.R. |e author |
700 | 1 | 0 | |a Zakaria, Z.A. |e author |
773 | |t Medical Principles and Practice |