From biophysical to integrate-and-fire modeling

From biophysical to integrate-and-fire modeling

This article proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the biophysical model to the modulation of parameters in the pr...

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Bibliographic Details
Main Authors: Drion, G. (Author), Sepulchre, R. (Author), Van Pottelbergh, T. (Author)
Format: Article
Language:English
Published: MIT Press Journals 2021
Subjects:
action potential
Action Potentials
biological model
Biophysical model
biophysics
Biophysics
Conductance parameters
Integrate-and-fire model
Low dimensional
Models, Neurological
Modulation
nerve cell
Neuromodulation
Neurons
Type II
Online Access:View Fulltext in Publisher
Description
Summary:This article proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the biophysical model to the modulation of parameters in the proposed integrate-and-fire model. The approach is illustrated on two well-documented examples of cellular neuromodulation: the transition between type I and type II excitability and the transition between spiking and bursting. © 2021 Massachusetts Institute of Technology.
ISBN:08997667 (ISSN)
DOI:10.1162/neco_a_01353

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