Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Microvascular thrombosis in patients with thrombotic thrombocytopenic purpura (TTP) is initiated by GPIbα-mediated platelet binding to von Willebrand factor (VWF). Binding of VWF to GPIbα causes activation of the platelet surface integrin αIIbβ3. However, the mechanism of GPIbα-initiated activation...

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Main Authors: Bergmeier, W. (Author), Chen, J. (Author), George, J.N (Author), Hoover, C. (Author), Kondo, Y. (Author), Lee, R.H (Author), López, J.A (Author), McDaniel, J.M (Author), McGee, S. (Author), Shan, X. (Author), Shao, B. (Author), Shi, H. (Author), Song, J. (Author), Vanhoorelbeke, K. (Author), Xia, L. (Author), Zhou, M. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Online Access:View Fulltext in Publisher

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