Evidence supporting a role for the immune checkpoint protein B7-H3 in NK cell-mediated cytotoxicity against AML

Evidence supporting a role for the immune checkpoint protein B7-H3 in NK cell-mediated cytotoxicity against AML

We observed that the immune checkpoint protein B7-H3 is overexpressed in acute myeloid leukemia (AML) patients with poor treatment outcomes. Inhibition of B7-H3 expression or blocking of its activity using a novel monoclonal antibody (T-1A5) in AML cells significantly enhanced natural killer (NK) ce...

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Bibliographic Details
Main Authors: Battula, V.L (Author), Bühring, H.-J (Author), El-Dana, F. (Author), Grimm, S. (Author), Jaggupilli, A. (Author), Konopleva, M. (Author), Ly, S. (Author), Tyagi, A. (Author), Yuan, B. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
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