Influenza in Malaysian adult patients hospitalized with community-acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease or asthma: a multicenter, active surveillance study
Background: Available data on influenza burden across Southeast Asia are largely limited to pediatric populations, with inconsistent findings. Methods: We conducted a multicenter, hospital-based active surveillance study of adults in Malaysia with community-acquired pneumonia (CAP), acute exacerbati...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BioMed Central Ltd
2021
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Series: | BMC Infectious Diseases
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Subjects: | |
Online Access: | View Fulltext in Publisher View in Scopus |
LEADER | 04784nam a2200985Ia 4500 | ||
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001 | 10.1186-s12879-021-06360-9 | ||
008 | 220121s2021 CNT 000 0 und d | ||
020 | |a 14712334 (ISSN) | ||
245 | 1 | 0 | |a Influenza in Malaysian adult patients hospitalized with community-acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease or asthma: a multicenter, active surveillance study |
260 | 0 | |b BioMed Central Ltd |c 2021 | |
490 | 1 | |a BMC Infectious Diseases | |
650 | 0 | 4 | |a adult |
650 | 0 | 4 | |a Adult |
650 | 0 | 4 | |a Adults |
650 | 0 | 4 | |a aged |
650 | 0 | 4 | |a Aged |
650 | 0 | 4 | |a Article |
650 | 0 | 4 | |a asthma |
650 | 0 | 4 | |a Asthma |
650 | 0 | 4 | |a Child, Preschool |
650 | 0 | 4 | |a chronic obstructive lung disease |
650 | 0 | 4 | |a clinical trial |
650 | 0 | 4 | |a community acquired infection |
650 | 0 | 4 | |a community acquired pneumonia |
650 | 0 | 4 | |a Community-Acquired Infections |
650 | 0 | 4 | |a comorbidity |
650 | 0 | 4 | |a complication |
650 | 0 | 4 | |a disease association |
650 | 0 | 4 | |a disease exacerbation |
650 | 0 | 4 | |a disease severity |
650 | 0 | 4 | |a dyspnea |
650 | 0 | 4 | |a Epidemiology |
650 | 0 | 4 | |a female |
650 | 0 | 4 | |a hospitalization |
650 | 0 | 4 | |a Hospitalization |
650 | 0 | 4 | |a human |
650 | 0 | 4 | |a Human |
650 | 0 | 4 | |a Humans |
650 | 0 | 4 | |a influenza |
650 | 0 | 4 | |a Influenza |
650 | 0 | 4 | |a influenza A (H1N1) |
650 | 0 | 4 | |a influenza A (H3N2) |
650 | 0 | 4 | |a Influenza A virus (H3N2) |
650 | 0 | 4 | |a Influenza A Virus, H3N2 Subtype |
650 | 0 | 4 | |a Influenza, Human |
650 | 0 | 4 | |a Influenza-like illness |
650 | 0 | 4 | |a intensive care unit |
650 | 0 | 4 | |a Intensive Care Units |
650 | 0 | 4 | |a major clinical study |
650 | 0 | 4 | |a Malaysia |
650 | 0 | 4 | |a Malaysian |
650 | 0 | 4 | |a male |
650 | 0 | 4 | |a Male |
650 | 0 | 4 | |a middle aged |
650 | 0 | 4 | |a Middle Aged |
650 | 0 | 4 | |a multicenter study |
650 | 0 | 4 | |a obstructive lung disease |
650 | 0 | 4 | |a Outcomes |
650 | 0 | 4 | |a pneumonia |
650 | 0 | 4 | |a Pneumonia |
650 | 0 | 4 | |a preschool child |
650 | 0 | 4 | |a Pulmonary Disease, Chronic Obstructive |
650 | 0 | 4 | |a risk factor |
650 | 0 | 4 | |a young adult |
856 | |z View Fulltext in Publisher |u https://doi.org/10.1186/s12879-021-06360-9 | ||
856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109330309&doi=10.1186%2fs12879-021-06360-9&partnerID=40&md5=5e0cab9ebe9a9d32010d03060cd74d7c | ||
520 | 3 | |a Background: Available data on influenza burden across Southeast Asia are largely limited to pediatric populations, with inconsistent findings. Methods: We conducted a multicenter, hospital-based active surveillance study of adults in Malaysia with community-acquired pneumonia (CAP), acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute exacerbation of asthma (AEBA), who had influenza-like illness ≤10 days before hospitalization. We estimated the rate of laboratory-confirmed influenza and associated complications over 13 months (July 2018–August 2019) and described the distribution of causative influenza strains. We evaluated predictors of laboratory-confirmed influenza and severe clinical outcomes using multivariate analysis. Results: Of 1106 included patients, 114 (10.3%) were influenza-positive; most were influenza A (85.1%), with A/H1N1pdm09 being the predominant circulating strain during the study following a shift from A/H3N2 from January–February 2019 onwards. In multivariate analyses, an absence of comorbidities (none versus any comorbidity [OR (95%CI), 0.565 (0.329–0.970)], p = 0.038) and of dyspnea (0.544 (0.341–0.868)], p = 0.011) were associated with increased risk of influenza positivity. Overall, 184/1106 (16.6%) patients were admitted to intensive care or high-dependency units (ICU/HDU) (13.2% were influenza positive) and 26/1106 (2.4%) died (2.6% were influenza positive). Males were more likely to have a severe outcome (ICU/HDU admission or death). Conclusions: Influenza was a significant contributor to hospitalizations associated with CAP, AECOPD and AEBA. However, it was not associated with ICU/HDU admission in this population. Study registration, NMRR ID: NMRR-17-889-35,174. © 2021, The Author(s). | |
700 | 1 | 0 | |a Chan, Y.F. |e author |
700 | 1 | 0 | |a Cheong, A. |e author |
700 | 1 | 0 | |a Chong, Y.M. |e author |
700 | 1 | 0 | |a Doshi, P. |e author |
700 | 1 | 0 | |a Ismail, A.I. |e author |
700 | 1 | 0 | |a Khor, J. |e author |
700 | 1 | 0 | |a Lau, J.Z.H. |e author |
700 | 1 | 0 | |a Leong, C.L. |e author |
700 | 1 | 0 | |a Musa, A.N. |e author |
700 | 1 | 0 | |a Ng, K.S. |e author |
700 | 1 | 0 | |a Pang, Y.K. |e author |
700 | 1 | 0 | |a Poh, M.E. |e author |
700 | 1 | 0 | |a Sam, I.-C. |e author |
700 | 1 | 0 | |a Tan, J.L. |e author |
700 | 1 | 0 | |a Taurel, A.-F. |e author |
700 | 1 | 0 | |a Wang, L.P.L. |e author |
700 | 1 | 0 | |a Zim, M.A.M. |e author |
773 | |t BMC Infectious Diseases |