Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

• Main Authors: Abdeeva, E. (Author), Andreeva, M. (Author), Apfelbacher, C. (Author), Avdeev, S. (Author), Baimukhambetova, D. (Author), Bairashevskaia, A. (Author), Bobkova, P. (Author), Bondarenko, E. (Author), Borzakova, S. (Author), Brackel, C.L.H (Author), Bugaeva, P. (Author), Bulanov, N. (Author), Buonsenso, D. (Author), Butnaru, D. (Author), Carson, G. (Author), Comberiati, P. (Author), Deunezhewa, S. (Author), DunnGalvin, A. (Author), El-Taravi, Y. (Author), Filippova, Y. (Author), Fomin, V. (Author), Gamirova, A. (Author), Genuneit, J. (Author), Glybochko, P. (Author), Greenhawt, M. (Author), Guekht, A. (Author), Kapustina, V. (Author), Korsunskiy, A.A (Author), Mazankova, L. (Author), Miroshina, A. (Author), Munblit, D. (Author), Needham, D.M (Author), Nekliudov, N. (Author), Olliaro, P. (Author), Osmanov, I.M (Author), Pazukhina, E. (Author), Peroni, D.G (Author), Petrova, P. (Author), Pikuza, M. (Author), Reyes, L.F (Author), Rumyantsev, M. (Author), Samitova, E. (Author), Scott, J.T (Author), Sechenov StopCOVID Research Team (Author), Semple, M.G (Author), Shikhaleva, A. (Author), Sigfrid, L. (Author), Spiridonova, E. (Author), Svistunov, A.A (Author), Timashev, P. (Author), Warner, J.O (Author)
• Format: Article
• Language: English
• Published: NLM (Medline) 2022
• Subjects: Adults; Children; COVID-19; COVID-19 sequelae; Long COVID; PASC; Post-acute sequelae of SARS-CoV-2 infection; Post-COVID-19 condition; Prevalence; Risk factor
• Online Access: View Fulltext in Publisher

 BACKGROUND: Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. METHODS: Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. RESULTS: One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47-53) in adults and 20% (95% CI 16-24) in children at 6 months, with decline to 34% (95% CI 31-37) and 11% (95% CI 8-14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). CONCLUSIONS: Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC. © 2022. The Author(s).