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01562nam a2200313Ia 4500 |
| 001 |
10.1186-s13059-022-02652-8 |
| 008 |
220511s2022 CNT 000 0 und d |
| 020 |
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|a 14747596 (ISSN)
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| 245 |
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|a SHOOT: phylogenetic gene search and ortholog inference
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| 260 |
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|b BioMed Central Ltd
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1186/s13059-022-02652-8
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|a Determining the evolutionary relationships between genes is fundamental to comparative biological research. Here, we present SHOOT. SHOOT searches a user query sequence against a database of phylogenetic trees and returns a tree with the query sequence correctly placed within it. We show that SHOOT performs this analysis with comparable speed to a BLAST search. We demonstrate that SHOOT phylogenetic placements are as accurate as conventional tree inference, and it can identify orthologs with high accuracy. In summary, SHOOT is a fast and accurate tool for phylogenetic analyses of novel query sequences. It is available online at www.shoot.bio. © 2022, The Author(s).
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|a algorithm
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|a Algorithms
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|a article
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|a Biological Evolution
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| 650 |
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|a evolution
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| 650 |
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|a orthology
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|a Orthology inference
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| 650 |
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|a phylogenetic tree
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| 650 |
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|a Phylogenetic tree inference
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| 650 |
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|a phylogeny
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| 650 |
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|a Phylogeny
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|a Sequence similarity search
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|a shoot
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| 650 |
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|a velocity
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| 700 |
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|a Emms, D.M.
|e author
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|a Kelly, S.
|e author
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| 773 |
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|t Genome Biology
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