CRISPR-mediated multigene integration enables Shikimate pathway refactoring for enhanced 2-phenylethanol biosynthesis in Kluyveromyces marxianus

CRISPR-mediated multigene integration enables Shikimate pathway refactoring for enhanced 2-phenylethanol biosynthesis in Kluyveromyces marxianus

Background: 2-phenylethanol (2-PE) is a rose-scented flavor and fragrance compound that is used in food, beverages, and personal care products. Compatibility with gasoline also makes it a potential biofuel or fuel additive. A biochemical process converting glucose or other fermentable sugars to 2-PE...

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Bibliographic Details
Main Authors: Da Silva, N. (Author), De Keyser, S. (Author), Lang, X. (Author), Li, M. (Author), Moran Cabrera, M. (Author), Sun, X. (Author), Wheeldon, I. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Amino acids
Biochemistry
Biofuels
Biosynthesis
Economical production
Expression regulation
Fed-batch operation
Feedback-insensitive
Flavor and fragrances
Flavor compounds
Flavors and fragrances
Fuel additives
gene expression
Gene expression
genetic engineering
genome
Integration
Kluyveromyces marxianus
Metabolic engineering
organic compound
Pathway engineerings
Personal care products
Shake-flask cultures
Strain
Thermotolerance
yeast
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