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10.1210-clinem-dgac157 |
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|a 19457197 (ISSN)
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|a BMI and Contraceptives Affect New Age-, Sex-, and Puberty-adjusted IGF-I and IGFBP-3 Reference Ranges Across Life Span
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|b NLM (Medline)
|c 2022
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|a CONTEXT: Various clinical factors influencing serum levels of insulin-like growth factor I (IGF-I) and its binding protein 3 (IGFBP-3) are not entirely consistently described. OBJECTIVE: We asked whether body mass index (BMI), contraceptive drugs (CDs), and hormone replacement therapy (HRT) have potential effects on data for interpreting new age-, sex-, and puberty-adjusted reference ranges for IGF-I and IGFBP-3 serum levels. DESIGN AND SETTING: Subjects were mainly participants from 2 population-based cohort studies: the LIFE Child study of children and adolescents and the LIFE Adult study. PARTICIPANTS: We investigated 9400 serum samples from more than 7000 healthy and 1278 obese subjects between 3 months and 81 years old. MAIN OUTCOME MEASURES: Associations between IGF-I or IGFBP-3, measured with a new electrochemiluminescence immunoassay, and the predictors BMI and CDs were estimated using hierarchical linear modeling. RESULTS: During infancy, obese children had up to 1 SD score (SDS) higher mean predicted IGF-I values, converging with levels of normal-weight subjects up to 13 years old. Between 20 and 40 years of age, obesity was related to up to -0.5 lower IGF-I SDS values than the predicted values. Obesity had less impact on IGFBP-3. Estrogen- and progestin-based CDs, but not HRT, decreased IGF-I and increased IGFBP-3 (P < 0.01) in adolescents (β IGF-I = -0.45, β IGFBP-3 = 0.94) and adults (β IGF-I = -0.43, β IGFBP-3 = 1.12). Conversely, progestin-based CDs were significantly positive associated with IGF-I (β IGF-I =0.82). CONCLUSIONS: BMI and CDs must be considered when assessing and interpreting the clinical relevance of IGF-I and IGFBP-3 measurements. © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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|a adolescent
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|a Adolescent
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|a adult
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|a Adult
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|a BMI
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|a body mass
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|a Body Mass Index
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|a child
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|a Child
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|a childhood obesity
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|a contraceptive agent
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|a Contraceptive Agents
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|a contraceptive drugs
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|a gestagen
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|a human
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|a Humans
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|a IGFBP-3
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|a IGF-I
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|a Insulin-Like Growth Factor Binding Protein 3
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|a Insulin-Like Growth Factor Binding Proteins
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|a Insulin-Like Growth Factor I
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|a longevity
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|a Longevity
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|a metabolism
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|a obesity
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|a Pediatric Obesity
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|a Progestins
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|a puberty
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|a Puberty
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|a reference ranges
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|a reference value
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|a Reference Values
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|a somatomedin binding protein
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|a somatomedin binding protein 3
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|a somatomedin C
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|a Ceglarek, U.
|e author
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|a Hörenz, C.
|e author
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|a Kiess, W.
|e author
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|a Kratzsch, J.
|e author
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|a Pfäffle, R.
|e author
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|a Thiery, J.
|e author
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|a Vogel, M.
|e author
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|a Wirkner, K.
|e author
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|t The Journal of clinical endocrinology and metabolism
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|z View Fulltext in Publisher
|u https://doi.org/10.1210/clinem/dgac157
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