Feasibility of the soft attention-based models for automatic segmentation of OCT kidney images

• Main Authors: Chen, Y. (Author), Du, X. (Author), Huan, T. (Author), Moradi, M. (Author)
• Format: Article
• Language: English
• Published: Optica Publishing Group (formerly OSA) 2022
• Subjects: article; attention; Automatic image analysis; Automatic segmentations; clinical evaluation; Convolution; convolutional neural network; Convolutional neural network; Convolutional neural networks; deep learning; Deep learning; feasibility study; human; human experiment; Human readers; image analysis; Image segmentation; kidney; Learning models; Morphometric parameters; Neural-networks; optical coherence tomography; Optical tomography; pattern recognition; Pattern recognition; Performance; recall; reliability; Segmentation accuracy; transplantation; Tubulars
• Online Access: View Fulltext in Publisher

 Clinically, optical coherence tomography (OCT) has been utilized to obtain the images of the kidney’s proximal convoluted tubules (PCTs), which can be used to quantify the morphometric parameters such as tubular density and diameter. Such parameters are useful for evaluating the status of the donor kidney for transplant. Quantifying PCTs from OCT images by human readers is a time-consuming and tedious process. Despite the fact that conventional deep learning models such as conventional neural networks (CNNs) have achieved great success in the automatic segmentation of kidney OCT images, gaps remain regarding the segmentation accuracy and reliability. Attention-based deep learning model has benefits over regular CNNs as it is intended to focus on the relevant part of the image and extract features for those regions. This paper aims at developing an Attention-based UNET model for automatic image analysis, pattern recognition, and segmentation of kidney OCT images. We evaluated five methods including the Residual-Attention-UNET, Attention-UNET, standard UNET, Residual UNET, and fully convolutional neural network using 14403 OCT images from 169 transplant kidneys for training and testing. Our results show that Residual-Attention-UNET outperformed the other four methods in segmentation by showing the highest values of all the six metrics including dice score (0.81 ± 0.01), intersection over union (IOU, 0.83 ± 0.02), specificity (0.84 ± 0.02), recall (0.82 ± 0.03), precision (0.81 ± 0.01), and accuracy (0.98 ± 0.08). Our results also show that the performance of the Residual-Attention-UNET is equivalent to the human manual segmentation (dice score = 0.84 ± 0.05). Residual-Attention-UNET and Attention-UNET also demonstrated good performance when trained on a small dataset (3456 images) whereas the performance of the other three methods dropped dramatically. In conclusion, our results suggested that the soft Attention-based models and specifically Residual-Attention-UNET are powerful and reliable methods for tubule lumen identification and segmentation and can help clinical evaluation of transplant kidney viability as fast and accurate as possible. © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement