A systems genomics approach uncovers molecular associates of RSV severity

A systems genomics approach uncovers molecular associates of RSV severity

Respiratory syncytial virus (RSV) infection results in millions of hospitalizations and thousands of deaths each year. Variations in the adaptive and innate immune response appear to be associated with RSV severity. To investigate the host response to RSV infection in infants, we performed a systems...

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Bibliographic Details
Main Authors: Benoodt, L. (Author), Caserta, M.T (Author), Chu, C.-Y (Author), Corbett, A. (Author), Falsey, A.R (Author), Gill, S.R (Author), Grier, A. (Author), Holden-Wiltse, J. (Author), Mariani, T.J (Author), McCall, M.N (Author), Qiu, X. (Author), Slaunwhite, C. (Author), Thakar, J. (Author), Topham, D.J (Author), Walsh, E.E (Author), Wang, L. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
adaptive immunity
Article
B lymphocyte receptor
cell activation
cohort analysis
controlled study
cytology
disease association
disease severity
gene expression regulation
genetics
genomics
Genomics
high throughput sequencing
human
Human respiratory syncytial virus
Humans
humoral immunity
Immunity, Innate
immunocompetent cell
immunology
infant
Infant
innate immunity
machine learning
Machine Learning
metabolism
Microbiota
microflora
molecular genetics
molecular pathology
Nasal Cavity
nonhuman
nose cavity
pathophysiology
procedures
respiratory epithelium
respiratory syncytial virus infection
Respiratory Syncytial Virus Infections
RNA-Seq
severity of illness index
Severity of Illness Index
signal transduction
Th17 cell
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