Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes

Background: Intrahepatic cholestasis of pregnancy (ICP) is a common disease affecting up to 5% of pregnancies and which can cause fetal arrhythmia and sudden intrauterine death. We previously demonstrated that bile acid taurocholate (TC), which is raised in the bloodstream of ICP, can acutely alter...

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Main Authors:	Abu-Hayyeh, S. (Author), Gorelik, J. (Author), Keitel, V. (Author), Miragoli, M. (Author), Moshkov, A.V (Author), Nikolaev, V.O (Author), Sheikh Abdul Kadir, S.H (Author), Williamson, C. (Author), Xie, Q. (Author)
Format:	Article
Language:	English
Subjects:	animal Animals Animals, Newborn Arrhythmias, Cardiac article bile acid Bile Acids and Salts cell nucleus Cell Nucleus chemically induced disorder cholestasis Cholestasis drug effect G protein coupled receptor gene silencing Gene Silencing genetics Gpbar1 protein, rat heart arrhythmia heart muscle cell metabolism muscarinic M2 receptor Myocytes, Cardiac newborn polymerase chain reaction Polymerase Chain Reaction rat Rats Rats, Wistar Receptor, Muscarinic M2 Receptors, G-Protein-Coupled signal transduction Signal Transduction Wistar rat
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Bile Acid-Induced Arrhythmia Is Mediated by Muscarinic M-2 Receptors in Neonatal Rat Cardiomyocytes

by Abu-Hayyeh, S, Gorelik, J, Kadir, SHSA, Keitel, V, Miragoli, M, Moshkov, AV, Nikolaev, VO, Williamson, C, Xie, QL

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Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes

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