Isolation of acetyl aleuritolic acid from Pimeleodendron griffithianum (Euphorbiaceae)

• Main Authors: Ahmat, N. (Author), Aziz, R.A (Author)
• Format: Article
• Language: English
• Published: Malaysian Society of Analytical Sciences 2016
• Subjects: Acetyl aleuritolic acid; Euphorbiaceae; Pimeleodendron griffithianum
• Online Access: View Fulltext in Publisher; View in Scopus

 Pimeleodendron griffithianum, locally known as Perah ikan is available in Thailand, Peninsular Malaysia and Sumatra. The plant can be found in wet forest, secondary forest, pole forest, semi-swamps, and along logging roads or on hill slopes. In Malaysia, the stem of P. griffithianum being used as commercial timber. So far, no chemical constituents have been reported from P. griffithianum. In this study, a phytochemical study was conducted on the stem bark of P. griffithianum. The stem bark was obtained from Sungai Siput, Perak. The cleaned, chopped and dried stem-bark was extracted using acetone for several times. The separation of the components was carried out using vacuum liquid chromatography (VLC) followed by recrystallization method. The structure of the pure compound was elucidated by spectroscopic methods including nuclear magnetic resonance (NMR), ultraviolate – visible (UV-Vis) and comparison with literature. One compound (1) was isolated and identified as acetyl aleuritolic acid. This compound was reported for the first time from this plant. © 2016, Malaysian Society of Analytical Sciences. All rights reserved.