Novel 7-Aryliden-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-aryl-2H-pyrazolo[4,3-c]pyridine Hydrochloride: Synthesis and Structure

• Main Authors: Beketov, K.M (Author), Berlin, K.D (Author), Iskakova, T.K (Author), Koshetova, Z.A (Author), Malmakova, A.E (Author), Praliyev, K.D (Author), Seilkhanov, T.M (Author), Yu, V.K (Author), Zhumanova, N.A (Author)
• Format: Article
• Language: English
• Published: al-Farabi Kazakh State National University 2022
• Subjects: 3a; 3-c] pyridine; 4; 5; 6; 7-(hexa-hydro-5-(2-ethoxyethyl)-2-phe-nyl-3-aryl-2H-pyrazolo[4; 7-arylidene-3; heterocyclisation; X-ray crystal structure
• Online Access: View Fulltext in Publisher
• ISBN: 15623920 (ISSN)
• DOI: 10.18321/ectj1147

A Claisen-Schmidt type reaction of 1-(2-ethoxyethyl)piperidin-4-one with differ-ent aromatic aldehydes led to corresponding dienones with a yield of 65‒71%. 7-Arylidene-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-aryl-2H-pyrazolo[4,3-c]pyridines were synthesized by heterocyclization of 3,5-dia-rylidene-piperidin-4-ones with phenylhydrazine hydrochloride in methanol at 70 °C over 4‒6 h. The X-ray crystal structure determination of 7-(p-methoxy-benzyliden)-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-(p-methoxy-phenyl)-2H-pyrazolo[4,3-c]pyridine hydrochloride (the deposition number is CCDC 862410) was completed. The piperidine and pyrazoline rings are close to a chair and envelope conformations, respectively. © 2022 Eurasian Chemico-Technological Journal.