Beetroot extracts as haematopoietic agents on rats
Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroot extracts as hematopoietic agents on...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada - Faculty of Pharmacy
2021
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |
| LEADER | 03194nam a2200577Ia 4500 | ||
|---|---|---|---|
| 001 | 10.22146-ijp.1132 | ||
| 008 | 220427s2021 CNT 000 0 und d | ||
| 020 | |a 23389427 (ISSN) | ||
| 245 | 1 | 0 | |a Beetroot extracts as haematopoietic agents on rats |
| 260 | 0 | |b Universitas Gadjah Mada - Faculty of Pharmacy |c 2021 | |
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.22146/ijp.1132 | ||
| 520 | 3 | |a Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroot extracts as hematopoietic agents on male rats. Methods: Beetroot dried powder was divided into two parts. One part was macerated separately with dichloromethane and 70% ethanol, while the other part was added with citric acid and washed with water to remove alkaloids and then extracted with 70% ethanol. The study used 24 rats which were divided into four groups. Each group consisted of 6 rats, namely the normal group, dichloromethane extract group, ethanolic extract group, and free alkaloids-ethanolic extract group. Each extract was given at a dose of 200 mg.Kg-1 for 21 days. Analyzed blood parameters are erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets. The data obtained consisted of the number of cells analyzed using one-way ANOVA then obtained by the Tukey test. Results: This study showed a significant increase in the number of erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets in rats that were given each extract compared to the normal group (p <0.05). The ethanolic extract of beetroot increased erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets by 41.49%, 24.95%, 14.92%, 33.54%, 27.19%, 59.40%, and 35.37%, respectively. Conclusions: The ethanolic extract of beetroot has the potential as a good natural haematopoietic agent. Copyright © 2020 The Author(S). | |
| 650 | 0 | 4 | |a alcohol |
| 650 | 0 | 4 | |a alkaloid |
| 650 | 0 | 4 | |a analysis of variance |
| 650 | 0 | 4 | |a animal cell |
| 650 | 0 | 4 | |a animal experiment |
| 650 | 0 | 4 | |a antianemic agent |
| 650 | 0 | 4 | |a Article |
| 650 | 0 | 4 | |a beetroot |
| 650 | 0 | 4 | |a Beetroots |
| 650 | 0 | 4 | |a Beta vulgaris extract |
| 650 | 0 | 4 | |a blood analysis |
| 650 | 0 | 4 | |a cell count |
| 650 | 0 | 4 | |a citric acid |
| 650 | 0 | 4 | |a clinical evaluation |
| 650 | 0 | 4 | |a controlled study |
| 650 | 0 | 4 | |a dichloromethane |
| 650 | 0 | 4 | |a drug synthesis |
| 650 | 0 | 4 | |a dry powder |
| 650 | 0 | 4 | |a erythrocyte |
| 650 | 0 | 4 | |a Extract |
| 650 | 0 | 4 | |a Haematopoietic |
| 650 | 0 | 4 | |a hemoglobin |
| 650 | 0 | 4 | |a hemoglobin blood level |
| 650 | 0 | 4 | |a ketamine |
| 650 | 0 | 4 | |a leukocyte |
| 650 | 0 | 4 | |a male |
| 650 | 0 | 4 | |a mean corpuscular hemoglobin |
| 650 | 0 | 4 | |a mean corpuscular hemoglobin concentration |
| 650 | 0 | 4 | |a mean corpuscular volume |
| 650 | 0 | 4 | |a nonhuman |
| 650 | 0 | 4 | |a plant extract |
| 650 | 0 | 4 | |a rat |
| 650 | 0 | 4 | |a thrombocyte |
| 650 | 0 | 4 | |a unclassified drug |
| 650 | 0 | 4 | |a water |
| 700 | 1 | |a Dwita, L.P. |e author | |
| 700 | 1 | |a Hikmawanti, N.P.E. |e author | |
| 700 | 1 | |a Zahra, D.A. |e author | |
| 773 | |t Indonesian Journal of Pharmacy | ||