| Summary: | Paitan (Tithonia diversifolia (Hemsley) A. Gray) extract is formulated to nanoemulsion to reduce the dose In-vivo diabetes mellitus treatment by increasing distribution and absorption. It is necessary due to concentrated extract is reported to be inefficient and harm the kidneys. Nanoemulsion was carried out by the ionic gelation method of chitosan crosslinking: Na-TPP: extract (5:1:1). It was successfully formed with a size of 346.0 nm, a polydispersity index of 0.406, and the zeta potential of +14.1 mV confirmed by particle size analyzer with dynamic light scattering method. Antioxidant evaluation with DPPH shows a value of IC50 16.801 ppm and is classified as an excellent antioxidant activity. The antidiabetic activity was evaluated In-vivo in Wistar strain rats and the results were analyzed using a One-Way ANOVA test of 95% confidence level. This nanoemulsion can reduce blood glucose levels up to 24% for 13 days at 150 mg/kg BW. This is more effective than glibenclamide (18%) (p> 0.05) as a positive control. Based on phytochemical screening, the extract contains alkaloids, tannins, terpenoids, and saponins. © 2021, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
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